MEMS Umbrella-Shaped Actuator with Active Structure for Medical Applications

适用于医疗应用的具有主动结构的 MEMS 伞形执行器

• 批准号: 0802168
• 负责人: Yong Shi
• 金额: $ 30万
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0802168&HistoricalAwards=false
• 关键词: MEMS; Umbrella; Shaped; Actuator; Active

The objective of this research is to design, fabricate and test an umbrella-shaped microactuator for thrombus retrieval in stroke therapy. The approach is to 1) design the actuator based on the properties of blood clots; 2) fabricate the actuator using an integrated micro/nanofabrication technique; and 3) demonstrate and improve the functionality and reliability of the actuator through in an in vitro vascular model. Intellectual Merit: The proposed actuator consists of active structures that are precisely controlled by novel piezoelectric nanofibers. The functional principle of the proposed actuator is unique in that it can provide a dynamic shear force on blood clots in vascular arteries. This shear force can be fine-tuned to facilitate the separation of the blood clot from the wall of the vascular artery due to the shearing-thinning phenomenon, thus enabling complete retrieval while minimizing the risk of damage to the arteries. This research will contribute new fundamental knowledge in the areas of piezoelectric response of nanomaterials as well as the mechanical behavior of blood clots.Broader Impact: Stroke is the third leading cause of death in the U.S, with blockage of arterial blood flow accounting for 83% of all strokes. If successful, this research will lead to a safe and reliable stroke therapy providing recanalization of blocked vascular arteries on the order of minutes. Educational materials based on this research will be implemented in courses at different levels and in different formats through various outreach programs and an existing NSF Nanotechnology Undergraduate Education program.

本研究的目的是设计、制造和测试一种用于中风治疗中血栓回收的伞状微致动器。该方法是1）基于血凝块的特性设计致动器; 2）使用集成的微/纳米纤维技术制造致动器;以及3）通过体外血管模型证明并改善致动器的功能性和可靠性。智力优点：所提出的致动器包括由新型压电纳米纤维精确控制的主动结构。所提出的致动器的功能原理是独特的，因为它可以在血管动脉中的血凝块上提供动态剪切力。该剪切力可以被微调以促进由于剪切稀化现象而导致的血凝块与血管动脉壁的分离，从而使得能够完全取回，同时最小化对动脉的损伤的风险。这项研究将为纳米材料的压电响应以及血液凝块的机械行为领域提供新的基础知识。更广泛的影响：中风是美国第三大死亡原因，动脉血流阻塞占所有中风的83%。如果成功的话，这项研究将导致一种安全可靠的中风治疗方法，在几分钟内实现阻塞血管的再通。基于这项研究的教育材料将通过各种推广计划和现有的NSF纳米技术本科教育计划在不同层次和不同形式的课程中实施。