International Conference: Mathematical tools for multi-scale biological processes, June 2008. Bozeman, MT

国际会议：多尺度生物过程的数学工具，2008 年 6 月。博兹曼，MT

• 批准号: 0803127
• 负责人: Tomas Gedeon
• 金额: $ 1.6万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0803127&HistoricalAwards=false
• 关键词: International; Conference; Mathematical; tools; multi

In the past twenty years biology has greatly benefited from insights gathered from mathematical models of biological processes. The unprecedented growth of molecular and systems biology in last 10 years challenges mathematicians to develop modeling techniques appropriate for the intricate biology on a cellular and sub-cellular level. It is increasingly clear that the processes in a living cell cannot be captured by static descriptions, but must be modeled as dynamical processes. This leads to descriptions by sets of differential equations, often with a stochastic component and including spatial dependencies. The conference will bring together mathematical biologists working on systems ranging from individual molecular processes to entire ecosystems. The aim of the conference is to facilitate the discovery of similarities between systems at these widely different scales.The revolution in genetic and molecular biology of the past decade promises a great advancement in medical science in the near future. The progress on many human diseases like cancer, Alzheimer's disease and genetic diseases is tied to our understanding of molecular mechanisms causing them. Every second of every day hundreds of chemical reactions in each cell sustain our lives. While we increasingly know who the players in these reactions are, we do not understand how they are controlled and regulated. Mathematical models can guide the necessary experiments that are needed to untangle this clockwork of interconnected processes. The conference will bring together the leading scientists in mathematical systems biology to exchange the ideas and establish new collaborations in order to help molecular biology to deliver on its medical promise. The conference participants constitute a diverse group of speakers in terms of gender, geographic origin, as well as career stages, and include members of underrepresented groups in science.

在过去的二十年里，生物学大大受益于从生物过程的数学模型中收集的见解。在过去的10年里，分子和系统生物学的空前发展向数学家们提出了挑战，要求他们在细胞和亚细胞水平上开发适合于复杂生物学的建模技术。越来越清楚的是，活细胞中的过程不能通过静态描述来捕获，而必须被建模为动态过程。这导致了用一组微分方程式来描述，通常带有随机成分，并包括空间相关性。这次会议将汇集数学生物学家，研究从单个分子过程到整个生态系统的各种系统。这次会议的目的是促进发现这些大不同规模的系统之间的相似之处。过去十年的遗传和分子生物学革命预示着在不久的将来医学科学将取得巨大进步。癌症、阿尔茨海默氏症和遗传病等许多人类疾病的进展与我们对导致这些疾病的分子机制的理解息息相关。每一天的每一秒，每个细胞中的数百个化学反应维持着我们的生命。虽然我们越来越了解这些反应中的参与者是谁，但我们不知道他们是如何受到控制和监管的。数学模型可以指导必要的实验，这些实验是解开这个相互关联的过程的发条所需的。这次会议将汇聚数学系统生物学领域的顶尖科学家，交流思想并建立新的合作关系，以帮助分子生物学实现其医学承诺。与会者在性别、地理来源以及职业阶段方面构成了一个不同的发言者群体，其中包括科学界代表性不足的群体的成员。