Dynamics and synchronization of biochemical oscillators

生化振荡器的动力学和同步

• 批准号: 0818785
• 负责人: Tomas Gedeon
• 金额: $ 15.68万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0818785&HistoricalAwards=false
• 关键词: Dynamics; synchronization; biochemical; oscillators

This project concerns the development of mathematical models of biochemical oscillations and the analysis required to understand their underlying behavior. While the list of molecular systems that exhibit oscillations is growing, the grasp of the common principles is challenged by the variety of underlying network structures. The presence of negative feedback is the only feature shared by all oscillatory networks; beyond this each system seems to be unique. The goal is to formulate a common principle that is shared by all oscillatory networks. It is expressed in terms of broad tendencies of the dynamics, rather then the detailed structure of the supporting networks. Cells constantly communicate with their environment and their neighbors. This mutual communication often results in synchronization of their behavior. A theory will be developed to explain synchronization of periodic signals in cell communities. The synchronization of biochemical oscillators will be studied via the nearest neighbor coupling, and the coupling with a communally produced and sensed molecule.A recent unprecedented explosion in our knowledge of structure and function of genetic regulatory networks promises revolutionary changes in how human disease is viewed and treated. Many biological processes ranging from the cell cycle to the human 24 hour circadian rhythm are periodic in time. This periodicity is driven by oscillations in the concentration of chemicals in individual cells. In many cases these signals synchronize across populations and the periodic signal can be detected on a macroscopic level. The regulatory networks that are responsible for production and maintenance of these rhythms are being discovered every day. While the structures of these networks vary, they often produce similar periodic signals. This project will study the underlying broad dynamics principles behind the oscillations, emphasizing the function of the network over its implementation. Further, it will study synchronization of the periodic rhythms in population of cells. The lack of synchronization in the population can result in developmental and functional defects. This project will develop a theory that will be able to predict collective dynamics, as well as suggest repair mechanisms in the case of failure.

这个项目涉及生化振荡的数学模型的发展，以及了解其潜在行为所需的分析。虽然表现出振荡的分子系统越来越多，但对共同原理的掌握受到各种潜在网络结构的挑战。负反馈的存在是所有振荡网络共有的唯一特征；除此之外，每个系统似乎都是独一无二的。我们的目标是制定一个所有振荡网络共享的共同原则。它是用动力学的广泛趋势来表示的，而不是用支持网络的详细结构来表示。细胞不断地与它们的环境和邻居交流。这种相互的交流往往导致他们的行为同步。将发展一种理论来解释细胞群落中周期信号的同步。生化振荡器的同步将通过最近邻耦合以及与共同产生和感知的分子的耦合来研究。最近，我们对基因调控网络的结构和功能的了解出现了前所未有的爆炸式增长，这预示着人类疾病的观察和治疗方式将发生革命性的变化。从细胞周期到人类24小时昼夜节律，许多生物过程在时间上都是周期性的。这种周期性是由单个细胞中化学物质浓度的振荡所驱动的。在许多情况下，这些信号在人群中同步，周期信号可以在宏观水平上检测到。负责产生和维持这些节律的调节网络每天都在被发现。虽然这些网络的结构各不相同，但它们经常产生相似的周期信号。该项目将研究振荡背后潜在的广泛动力学原理，强调网络的功能而不是其实施。此外，它将研究细胞群体周期节律的同步性。在人群中缺乏同步性会导致发育和功能缺陷。该项目将发展一种理论，能够预测集体动态，并提出故障情况下的修复机制。