Organization, Dynamics and Translocation at Fluid Interfaces

在分析和表面化学计划的支持下，本研究对负载型脂质双分子膜的组织和动力学进行了研究。脂质双分子层对生命至关重要，支持的双分子层结构在生物传感应用中至关重要。这些分子层已被广泛研究，但这些膜内分子相互作用与其宏观行为之间的联系仍有待建立。密歇根州立大学的Blanchard教授和他的研究小组专注于理解单层囊泡和支撑脂质双层的结构、动力学和相分离行为，作为层组成和底物化学结构的函数。该小组评估了包括荧光探针分子在内的模型双层内以及双层与底物之间的分子相互作用，这些相互作用负责双层的组织和动力学。所有这些努力的一个共同线索是双层动力学和组织是由双层结构缺陷位点介导的假设。除了了解脂质双分子层组织和动态之外，该研究项目的更大目的是教育处于界面科学前沿的学生，培养具有全球竞争力的学生群体，这些学生反映了美国科学事业的人口结构。这项研究是这种努力的载体。这项工作的结果将形成本科研究报告，硕士论文，博士论文，并将在同行评审的文献中报告。这个研究项目是面向本科生和研究生的，项目负责人所在的机构强烈支持本科生参与研究，以确保早期接触多学科科学。密歇根州立大学化学研究生课程和该机构作为一个整体，长期以来一直致力于包容代表性不足的群体，在过去的七年里，布兰查德研究小组的女性比例超过50%。该小组与Pawel教授Krysiñski（华沙大学）进行了持续的国际合作，重点是使用生物和仿生界面进行化学传感。Krysiñski小组的专业知识与Blanchard小组相吻合，这种合作增强了两个实验室的广度。来自两个小组的学生定期在合作实验室工作，为美国和波兰学生培养全球科学视野，加速基础知识的传播。

In this research supported by the Analytical and Surface Chemistry Program, the organization and dynamics of supported lipid bilayer films are investigated. Lipid bilayers are essential to life and supported bilayer structures are of critical importance in biosensing applications. These molecular layers have been studied widely but the connection between molecular interactions within these films and their macroscopic behavior remains to be established. Prof. Blanchard and his group at Michigan State University focus in this research on understanding the structure, dynamics and phase separation behavior in unilamellar vesicles and supported lipid bilayers as a function of layer composition and substrate chemical structure. The group evaluates, including with fluorescent probe molecules, the molecular interactions within model bilayers and between the bilayer and substrate that are responsible for bilayer organization and dynamics. A common thread to all of these efforts is the hypothesis that bilayer dynamics and organization are mediated by structural defect sites within the bilayers.The larger purpose of this research program, beyond understanding lipid bilayer organization and dynamics, is to educate students at the cutting edge of interfacial science to train a globally competitive cohort of students that reflects the demographic of the Nation for careers in science. This research serves as a vehicle in that effort. Results from this work will form undergraduate research reports, MS theses, PhD dissertations and will be reported in the peer-reviewed literature. This research program is geared for participation by undergraduate and graduate students, and the PI's home institution is strongly supportive of the inclusion of undergraduates in research, ensuring early exposure to multidisciplinary science. The MSU Graduate Program in Chemistry and the Institution as a whole has a long-standing commitment to the inclusion of under-represented groups, and for the past seven years the Blanchard research group has been more than 50% female. The group has an ongoing International collaboration with Professor Pawel Krysiñski (University of Warsaw) that focuses on the use of biological and biomimetic interfaces for chemical sensing. The Krysiñski group expertise dovetails with the Blanchard group, and this collaboration enhances the breadth of both labs. Students from both groups work regularly in the collaborator labs, fostering a global scientific outlook for both US and Polish students and accelerating the movement of fundamental knowledge.