Controlling Organization and Dynamics in Fluid Interfaces

控制流体界面的组织和动态

• 批准号: 0445492
• 负责人: Gary Blanchard
• 金额: $ 36万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0445492&HistoricalAwards=false
• 关键词: Controlling; Organization; Dynamics; Fluid; Interfaces

Professor Gary Blanchard of Michigan State University is supported by the Analytical and Surface Chemistry program to construct and then optically characterize a set of monolayer and bilayer fluid interfaces. Hybrid lipid bilayer structures have been created and characterized for over a decade, however, there is still a great deal unknown regarding relationships between membrane composition and physical properties. The PI seeks to establish a linked set of time-resolved fluorescence spectroscopic and imaging measurements in order to extract information about the local environment and its dynamics via fluorescent probes. The optical approaches include epifluorescence microscopy, photobleaching experiments and two-photon fluorescence experiments. The work is being done in collaboration with Prof. Pawel Kryskinski of the Polish Academy of Sciences.Control over rationally constructed mono- and bi-layer fluid interfaces will benefit biotechnology, biosensor development and efforts to make artificial cell mimicks. These experiments provide fundamental underpinnings for applications such as drug delivery and medical implants.

密歇根州立大学的加里布兰查德教授在分析和表面化学项目的支持下，构建了一组单层和双层流体界面，并对其进行了光学表征。混合脂质双层结构已经被创建和表征了十多年，然而，关于膜组成和物理性质之间的关系仍然有很多未知。 PI旨在建立一套时间分辨荧光光谱和成像测量的链接，以便通过荧光探针提取有关当地环境及其动态的信息。 光学方法包括落射荧光显微术、光漂白实验和双光子荧光实验。 这项工作是与波兰科学院的Pawel Kryskinski教授合作完成的，对合理构建的单层和双层流体界面的控制将有利于生物技术、生物传感器的开发和制造人工细胞模拟物的努力。 这些实验为药物输送和医疗植入等应用提供了基础。