Green Catalysis

绿色催化

• 批准号: 0809901
• 负责人: L. Keith Woo
• 金额: --
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809901&HistoricalAwards=false
• 关键词: Green; Catalysis

This award by the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports Professor L. Keith Woo at Iowa State University for the development of environmentally-friendly, sustainable approaches to catalytic processes and technologies. Biological systems provide the inspiration and insight into the "green" catalyst design employed by the Woo research group. The first project is based on the central role of iron porphyrins (heme) as the active sites in a variety of vital enzymes such as cytochrome P-450 and peroxidases. A diverse group of postdoctoral, graduate, and undergraduate students will investigate new catalytic applications of these versatile compounds. The second project will accelerate the development, optimization, and production of effective catalysts using molecular iterations. This strategy provides a large random library of single-stranded DNA (ssDNA) oligomers which can act as water-soluble catalysts for organic reactions. By involving a massive collection of different DNA molecules in an inherently selective and high-throughput process, maximal structural and compositional diversity can be rapidly screened. Such screening can dramatically reduce the time for catalyst identification and development. Combinatorial approaches such as these have made great impacts on drug design, but its use in transition metal catalyst design is in its infancy. These research projects foster teamwork and cooperation among Professor Woo's students at Iowa State University and exemplifies interdisciplinary collaboration with chemists, biochemists, biologists, and engineers.

这个奖项由无机，生物无机和有机化学计划支持教授L。基思吴在爱荷华州州立大学的环境友好，可持续的方法，催化过程和技术的发展。 生物系统为Woo研究小组采用的“绿色”催化剂设计提供了灵感和见解。 第一个项目是基于铁卟啉（血红素）作为各种重要酶如细胞色素P-450和过氧化物酶的活性位点的中心作用。 一组不同的博士后，研究生和本科生将研究这些多功能化合物的新催化应用。 第二个项目将利用分子迭代加速有效催化剂的开发、优化和生产。 这种策略提供了一个大的单链DNA（ssDNA）低聚物的随机文库，可以作为有机反应的水溶性催化剂。 通过在固有的选择性和高通量过程中涉及不同DNA分子的大量集合，可以快速筛选最大的结构和组成多样性。 这种筛选可以显著减少催化剂鉴定和开发的时间。 诸如此类的组合方法对药物设计产生了巨大影响，但其在过渡金属催化剂设计中的应用仍处于起步阶段。 这些研究项目促进了吴教授在爱荷华州州立大学的学生之间的团队合作，并加强了化学家、生物化学家、生物学家和工程师的跨学科合作。