Metal Oxo and Peroxo Chemistry: Reactivity and Catalysis

爱荷华州立大学的L.Keith Woo得到了无机化学、生物无机化学和金属有机化学计划的支持，该计划旨在研究过渡金属卟啉配合物介导的化学氧化。氧金属卟啉是多种酶过程中的重要活性中间体，特别是细胞色素P450家族。早期过渡金属，特别是钛(IV)、铬(IV)和钒(IV)的氧金属卟啉可以利用分子氧来氧化有机底物，特别是二醇。Woo专注于三个过程：1)金属氧络合物催化的氧化裂解反应，2)金属过氧基和烷基过氧基络合物的氧原子转移，以及3)NO和过氧基络合物之间的反应。氧化在工业和生物化学上都是至关重要的，但许多这些反应的细节还不是很清楚。对所涉及的化学步骤的透彻理解可能会提高我们优化这些重要过程、保护自然资源和消除浪费的能力。通过这个项目，研究生和本科生将在实验室接受培训，并将发展成为独立科学家所需的沟通和智力技能。

L. Keith Woo, Iowa State University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program for studies of chemical oxidations mediated by transition metal porphyrin complexes. Oxometalloporphyrins are important active intermediates in several enzymatic processes, particularly the cyctochrome P450 family. Oxometalloporphyrins of the early transition metals, particularly titanium (IV), chromium (IV) and vanadium (IV) can utilize molecular oxygen in oxidations of organic substrates, particularly diols. Woo is focusing on three processes: 1)oxidative cleavage reactions catalyzed by metal oxo complexes, 2) oxygen atom transfer from metal peroxo and alkyl peroxo complexes, and 3) studies on the reactions between NO and peroxo complexes.Oxidations are critically important both industrially and biochemically, yet the details of many of these reactions are not well-understood. A thorough comprehension of the chemical steps involved may advance our abilities to optimize these important processes, conserve natural resources and eliminate waste. Through this project, graduate students and undergraduates will be trained in the laboratory and will develop communication and intellectual skills needed to become independent scientists.