SBIR Phase I: Chemically Selective Litmus Paper for Exposure Monitoring

SBIR 第一阶段：用于暴露监测的化学选择性石蕊试纸

• 批准号: 0810586
• 负责人: Thomas Horn
• 金额: --
• 依托单位: Kalinex, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0810586&HistoricalAwards=false
• 关键词: SBIR; Phase; Chemically; Selective; Litmus

This Small Business Innovation Research Phase I research project uses a new approach based on evolutionary screening of biomolecular receptors mimicking molecular recognition in biology for gas-phase chemical analysis. This approach has led to the discovery of various short peptide sequences that are shown to be highly selective to gas molecules due to multivalent binding. When liposomes of conjugated polymers such as polydiacetylene (PDA) are distorted due to ligand-receptor binding on their surface, a blue-to-red color change is induced. The innovation in this project is to combine the short peptide receptors with the PDA liposomes to create chemically-selective color-changing "litmus paper" for detecting carcinogens and other chemicals in indoor environments and for personal exposure monitoring of susceptible populations. Of the five human senses, those related to smell and taste have not been replicated in miniature devices, mainly due to the lack of selectivity. Chemical analysis is currently achieved using gas chromatography-mass spectrometry. Because such systems are large and expensive, chemical analysis has largely remained in the lab and in centralized facilities. The technology for chemically selective coatings proposed here has the potential to fundamentally change that, and lead to low-cost sensor systems that are portable and ubiquitous. These microsystems can decentralize chemical analysis of air-borne chemicals related to volatile explosives, toxins, pesticides, chemicals, food spoilage products, metabolite biomarkers for disease states, flavoring agents and cosmetics.

这个小企业创新研究第一阶段研究项目采用了一种基于生物分子受体进化筛选的新方法，模拟生物学中的分子识别进行气相化学分析。这种方法导致了各种短肽序列的发现，这些短肽序列由于多价结合而对气体分子具有高度选择性。当聚二乙炔（PDA）等共轭聚合物的脂质体由于其表面上的配体-受体结合而变形时，会引起蓝到红的颜色变化。该项目的创新之处在于将短肽受体与PDA脂质体结合起来，创建化学选择性变色“石蕊试纸”，用于检测室内环境中的致癌物和其他化学物质，以及对易感人群进行个人暴露监测。在人类的五种感官中，与嗅觉和味觉相关的感官尚未在微型设备中复制，这主要是由于缺乏选择性。目前化学分析是使用气相色谱-质谱法来实现的。由于此类系统庞大且昂贵，化学分析大部分保留在实验室和集中设施中。这里提出的化学选择性涂层技术有可能从根本上改变这一现状，并带来便携式且无处不在的低成本传感器系统。这些微系统可以对与挥发性爆炸物、毒素、杀虫剂、化学品、食品腐败产物、疾病状态代谢生物标志物、调味剂和化妆品相关的空气中化学物质进行分散化学分析。