Enhancing Research and Education at the University of Alaska Anchorage with a state-of-the-art Liquid Chromatograph-Ion Trap Mass Spectrometer

使用最先进的液相色谱-离子阱质谱仪加强阿拉斯加大学安克雷奇分校的研究和教育

• 批准号: 0813850
• 负责人: Birgit Hagedorn
• 金额: $ 41.15万
• 依托单位: University of Alaska Anchorage Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0813850&HistoricalAwards=false
• 关键词: Enhancing; Research; Education; University; Alaska

With this award from the Major Research Instrumentation program (MRI), Birgit Hagedorn and colleagues Marc C. Perry, Donald E. Spallinger and Jeffrey M. Welker from the University of Alaska Anchorage (UAA) Campus will acquire high performance liquid chromatography coupled to a tandem mass spectrometer (LC/MS/MS). Mass spectrometry provides powerful compound identification and quantification based on the masses of various fragments as well as for determining the molecular weight of the components of complex mixtures such as lipids, persistent organic pollutants, and tannins which are currently research topics of UAA faculty and students. Furthermore, the mass spectrometer will be combined with an ion chromatograph (IC) to separate anions, such as toxic perchlorate at low concentration in complex matrixes, which is another active research topic at UAA. The spectrometer is ideal because it provides different modes of ionization with a sensitivity of 250 femtograms over a wide mass range (m/z 50-2200). The instrument will be hosted in the Applied Science, Engineering, and Technology (ASET) Laboratory at UAA where a laboratory manager and chemist will provide the knowledge and skills needed to establish methods, maintain the performance of this instrument, and train faculty and students.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. It is one of the fastest growing and most widely used analytical instrumentation techniques. Because of this, it is important for undergraduate and master students to be exposed to the technique. To a first approximation a tandem mass spectrometer can be thought of as two mass spectrometers in series connected by a chamber that can break a molecule into pieces.

获得这项由主要研究仪器计划（MRI）颁发的奖项后，Birgit哈格多恩和他的同事Marc C.作者声明：佩里作者声明：Jeffrey M.来自阿拉斯加大学安克雷奇分校（UAA）的Welker将获得与串联质谱仪（LC/MS/MS）耦合的高效液相色谱。质谱法提供了强大的化合物鉴定和定量的基础上的各种片段的质量，以及确定复杂的混合物，如脂质，持久性有机污染物和单宁的成分的分子量，这是目前UAA教师和学生的研究课题。此外，质谱仪将与离子色谱仪（IC）相结合，以分离阴离子，如复杂基质中低浓度的有毒高氯酸盐，这是UAA的另一个活跃的研究课题。光谱仪是理想的，因为它提供了不同的电离模式，在宽质量范围（m/z 50-2200）内的灵敏度为250毫微微克。该仪器将在UAA的应用科学，工程和技术（ASET）实验室托管，实验室经理和化学家将提供建立方法所需的知识和技能，维护该仪器的性能，并培训教师和学生。质谱（MS）是一种用于探测亲密结构细节并获得大量有机物分子组成的技术，生物有机和有机金属分子。 它是发展最快、使用最广泛的分析仪器技术之一。 正因为如此，本科生和硕士生接触这项技术非常重要。串联质谱仪可以被认为是由一个可以将分子分解成碎片的腔室串联连接的两个质谱仪。