MRI: Acquisition of a Cyber-Enabled Mass Spectrometer Facility

MRI：购置网络质谱仪设施

• 批准号: 0821515
• 负责人: Stuart Rowan
• 金额: $ 26.5万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821515&HistoricalAwards=false
• 关键词: MRI; Acquisition; Cyber; Enabled; Mass

With this award from the Major Research Instrumentation program (MRI), Stuart J. Rowan and colleagues John D. Protasiewicz and Gregory P. Tochtrop from Case Western Reserve University have submitted a proposal in response to the MRI solicitation to acquire a Cyber-enabled mass spectrometry facility consisting of a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF/TOF) instrument to be used for the study of biological and non-biological complex polymeric systems and for detailed characterization of compounds, e.g., macromolecules, peptide polymer hybrids, which can be difficult to achieve by other techniques. Eighteen major users and students from departments including Macromolecular Science and Engineering, Chemistry, Biomedical Engineering and the Medical School will use the spectrometer.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry.

凯斯西储大学的Stuart J.Rowan及其同事John D.Protasiewicz和Gregory P.Tochtrop获得了重大研究仪器计划(MRI)颁发的这一奖项，他们响应MRI的邀请提交了一份建议书，拟购买一台由基质辅助激光解吸/电离飞行时间(MALDI-TOF/TOF)仪器组成的网络质谱仪，用于研究生物和非生物复杂聚合物体系，并详细表征化合物，例如大分子、多肽聚合物杂合物，这是通过其他技术难以实现的。来自高分子科学与工程、化学、生物医学工程和医学院等系的18名主要用户和学生将使用该光谱仪。MALDI-TOF-MS是获得超大分子精确分子量的首选技术，具有极高的灵敏度。因此，使用MALDI-TOF质谱计已成为一种标准技术，特别是在涉及生物分子的研究中。这项研究将在许多领域产生重大影响，特别是化学和生物化学。