MRI: Acquisition of a Cyber-Enabled Mass Spectrometer Facility

有了这个主要研究仪器项目（MRI）的奖项，来自Case Western Reserve大学的Stuart J. Rowan及其同事John D. Protasiewicz和Gregory P. Tochtrop提交了一份提案，以响应MRI的请求，获得一个网络支持的质谱设备，该设备由基质辅助激光解吸/电离飞行时间（MALDI-TOF/TOF）仪器组成，用于研究生物和非生物复杂聚合物系统，并详细表征化合物，例如大分子，多肽聚合物的杂化，这是其他技术难以实现的。来自大分子科学与工程、化学、生物医学工程和医学院等系的18名主要用户和学生将使用该光谱仪。maldi - tof质谱法是在非常大的分子上获得准确分子量的首选技术，具有极高的灵敏度。因此，使用MALDI-TOF质谱仪已成为一种标准技术，特别是在涉及生物分子的研究中。这项研究将在许多领域产生重大影响，特别是化学和生物化学。

With this award from the Major Research Instrumentation program (MRI), Stuart J. Rowan and colleagues John D. Protasiewicz and Gregory P. Tochtrop from Case Western Reserve University have submitted a proposal in response to the MRI solicitation to acquire a Cyber-enabled mass spectrometry facility consisting of a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF/TOF) instrument to be used for the study of biological and non-biological complex polymeric systems and for detailed characterization of compounds, e.g., macromolecules, peptide polymer hybrids, which can be difficult to achieve by other techniques. Eighteen major users and students from departments including Macromolecular Science and Engineering, Chemistry, Biomedical Engineering and the Medical School will use the spectrometer.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry.