MRI: Acquisition of a Cyber-Enabled Mass Spectrometer Facility

MRI：购置网络质谱仪设施

• 批准号: 0821515
• 负责人: Stuart Rowan
• 金额: $ 26.5万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821515&HistoricalAwards=false
• 关键词: MRI; Acquisition; Cyber; Enabled; Mass

With this award from the Major Research Instrumentation program (MRI), Stuart J. Rowan and colleagues John D. Protasiewicz and Gregory P. Tochtrop from Case Western Reserve University have submitted a proposal in response to the MRI solicitation to acquire a Cyber-enabled mass spectrometry facility consisting of a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF/TOF) instrument to be used for the study of biological and non-biological complex polymeric systems and for detailed characterization of compounds, e.g., macromolecules, peptide polymer hybrids, which can be difficult to achieve by other techniques. Eighteen major users and students from departments including Macromolecular Science and Engineering, Chemistry, Biomedical Engineering and the Medical School will use the spectrometer.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry.

凭借重大研究仪器计划（MRI）的奖项，Stuart J. Rowan及其同事John D. Protasiewicz和Gregory P. Tochtrop case Western Reserve University的Tochtrop提出了一项提案，以响应MRI征服，以获取网络启用的质谱设施，该设施由成熟的仪表仪供应/乘坐的仪器供应量/级别的仪表式供应量/小时，以供应量/地区的仪表型（均可及时）。生物和非生物复合物聚合系统的研究以及化合物的详细表征，例如大分子，肽聚合物混合体，其他技术可能难以实现。来自分子科学和工程，化学，生物医学工程和医学院等部门的十八位主要用户和学生将使用光谱仪。Maldi-TOF-MAS-MASS光谱法是在非常大的分子上获得准确的分子量的首选技术，具有极高的敏感性。因此，使用MALDI-TOF质谱仪已成为一种标准技术，尤其是在涉及生物分子的研究中。这项研究将对许多领域，尤其是化学和生物化学产生重大影响。