MRI: Acquisition of a Cyber-Enabled Mass Spectrometer Facility

获得这项由主要研究仪器计划（MRI）颁发的奖项，斯图尔特J罗文和同事约翰D。来自凯斯西储大学的Protasiewicz和Gregory P. Tochtrop已经提交了一份提案，以响应MRI招标，以获得由基质辅助激光解吸/电离飞行时间（MALDI-TOF/TOF）仪器组成的网络化质谱设备，用于生物和非生物复杂聚合物系统的研究以及化合物的详细表征，例如，大分子、肽聚合物杂化物，这可能难以通过其他技术实现。来自高分子科学与工程、化学、生物医学工程和医学院等部门的18名主要用户和学生将使用该光谱仪。MALDI-TOF-质谱法是获得非常大分子的精确分子量的首选技术，具有极高的灵敏度。因此，MALDI-TOF质谱仪的使用已成为标准技术，特别是在涉及生物分子的研究中。这项研究将在许多领域产生重大影响，特别是化学和生物化学。

With this award from the Major Research Instrumentation program (MRI), Stuart J. Rowan and colleagues John D. Protasiewicz and Gregory P. Tochtrop from Case Western Reserve University have submitted a proposal in response to the MRI solicitation to acquire a Cyber-enabled mass spectrometry facility consisting of a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF/TOF) instrument to be used for the study of biological and non-biological complex polymeric systems and for detailed characterization of compounds, e.g., macromolecules, peptide polymer hybrids, which can be difficult to achieve by other techniques. Eighteen major users and students from departments including Macromolecular Science and Engineering, Chemistry, Biomedical Engineering and the Medical School will use the spectrometer.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry.