SGER: Design of Protein-Based Nanoscale Drug Carriers

SGER：基于蛋白质的纳米药物载体的设计

• 批准号: 0827852
• 负责人: Szu-Wen Wang
• 金额: $ 20万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0827852&HistoricalAwards=false
• 关键词: SGER; Design; Protein; Based; Nanoscale

CBET-0827852WangThis project investigates the use of a model protein system which has never been used before as a scaffold in nanobiotechnology. While the Principal Investigator (PI) has already established this expression system in the PI?s laboratory, and has demonstrated its ability to hold model drug molecules, this project still contains a number of untested ideas. Further research needs to be performed to establish the feasibility and kinetics of drug release, drug encapsulation efficiency, incorporation of multiple types of drug molecules, and the ability to modulate protein assembly and disassembly.

这个项目研究了一种以前从未被用作纳米生物技术支架的模型蛋白质系统的使用。而首席研究员（PI）已经在PI中建立了这个表达系统。尽管该项目已经证明了其储存模型药物分子的能力，但它仍包含许多未经验证的想法。需要进一步的研究来确定药物释放的可行性和动力学，药物包封效率，多种药物分子的掺入，以及调节蛋白质组装和拆卸的能力。