Molecular Design of Self-Assembling Biomimetic Polymers

自组装仿生聚合物的分子设计

• 批准号: 0706669
• 负责人: Szu-Wen Wang
• 金额: $ 42万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0706669&HistoricalAwards=false
• 关键词: Molecular; Design; Self; Assembling; Biomimetic

This award to University of California Irvine by the Biomaterials program in the Division of Materials Research is to create artificial collagens that can specify and enhance cellular activity, a critical component of furthering applications such as tissue regeneration and drug delivery. Collagen is a naturally-occurring material which can impart specific biochemical and mechanical signals. While these features suggest that this biopolymer is a choice material for use in drug delivery and regenerative medicine, properties related to tensile strength and nanoscale structure can limit applicability. Furthermore, the synthetic design and production of collagen-based biopolymers has exhibited challenges not associated with other protein-based polymers, primarily because of the stringent need to correctly post-translationally modify the backbone for correct assembly, structure, and function. To address these limitations, this award will use a yeast expression system to create recombinant collagen-like biopolymers. Mechanical strength and structural properties will be modulated by incorporating natural cross-linkers of varying architectures. The proposed functional modifications upon this scaffold will expand the scope of material properties to include mechanical and structural ranges that are not naturally available.The capability to create and investigate the fundamental properties of bioresponsive materials is critical for advancing areas such as regenerative medicine, therapies for disease, and biosensors. By creating novel collagen-like polymers of precise architectures using a yeast expression system, this award is planning to obtain mechanical and structural properties not naturally observed while simultaneously preserving collagen's natural ability to elicit biological responses. The project will involve both undergraduate and graduate students in the research. Due to the interdisciplinary nature of this collaboration, students participating in this research will gain an integrated perspective of the important interfaces and synergies between diverse fields. Results from this proposed work will also be incorporated into two graduate courses.

该奖项由材料研究部的生物材料项目授予加州尔湾大学，旨在创造可以指定和增强细胞活性的人工胶原蛋白，这是进一步应用的关键组成部分，如组织再生和药物输送。 胶原蛋白是一种天然存在的材料，可以传递特定的生物化学和机械信号。 虽然这些特征表明这种生物聚合物是用于药物递送和再生医学的首选材料，但与拉伸强度和纳米级结构相关的特性可能会限制其适用性。 此外，基于胶原蛋白的生物聚合物的合成设计和生产已经表现出与其他基于蛋白质的聚合物不相关的挑战，主要是因为严格需要正确地对主链进行后修饰以实现正确的组装、结构和功能。 为了解决这些限制，该奖项将使用酵母表达系统来创建重组胶原蛋白样生物聚合物。 机械强度和结构性能将通过结合不同结构的天然交联剂来调节。 在这种支架上提出的功能修改将扩大材料特性的范围，包括机械和结构的范围，而不是自然available.The能力，创造和研究生物响应材料的基本性能是至关重要的，推进领域，如再生医学，疾病的治疗，和生物传感器。 通过使用酵母表达系统创建具有精确结构的新型胶原蛋白样聚合物，该奖项计划获得自然观察不到的机械和结构特性，同时保留胶原蛋白引发生物反应的天然能力。 该项目将涉及本科生和研究生的研究。 由于这种合作的跨学科性质，参与这项研究的学生将获得不同领域之间的重要接口和协同作用的综合视角。 这项拟议工作的成果也将纳入两个研究生课程。