Modulating Cellular Response Using Tunable Collagen-Based Biopolymers

使用可调节的胶原蛋白生物聚合物调节细胞反应

• 批准号: 1034566
• 负责人: Szu-Wen Wang
• 金额: $ 45万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-01 至 2015-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1034566&HistoricalAwards=false
• 关键词: Modulating; Cellular; Response; Using; Tunable

1034566WangThis research can have a major impact on the area of biomimetic materials associated with regenerative medicine and disease therapy, and in this regard it shows great transformative potential. The approach described allows for the creation of a multitude of collagen-like proteins by interchanging DNA modules, and holds promise for overcoming limitations associated with use of native collagen-based materials, most notably the inability to independently control mechanical properties and the concentration of biologically active sites.

1034566Wang这项研究可以对与再生医学和疾病治疗相关的仿生材料领域产生重大影响，在这方面，它显示出巨大的变革潜力。所描述的方法允许通过互换DNA模块来产生大量胶原蛋白样蛋白，并且有望克服与使用天然胶原蛋白基材料相关的限制，最显著的是不能独立控制机械性质和生物活性位点的浓度。