Development of highly efficient Aquaporin based membranes for Aqueous Separations

开发用于水分离的高效水通道蛋白基膜

• 批准号: 0828512
• 负责人: Mark Clark
• 金额: $ 40万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0828512&HistoricalAwards=false
• 关键词: Development; highly; efficient; Aquaporin; based

CBET- 0828512ClarkAqueous separation processes are increasingly used for water and wastewater treatment and for medical, industrial, and municipal applications such as dialysis, high-quality water preparation, ethanol concentration, and juice and aroma concentration. The use of reverse osmosis (RO), a pressure-driven aqueous separation processes, is limited by low productivities of existing membranes and the high energy consumption for maintaining operating pressures. The principal objective of this proposal is to develop advanced reverse osmosis membrane (ROM) technology for water and wastewater treatment. The overall hypothesis of the proposed study is that highly efficient solute-rejecting osmotic membranes can be developed by incorporating biological water-channel proteins (Aquaporins or AQPs) into synthetic polymers. The proposed research consists of two major research tasks. In the first task insertion of AqpZ into ABA polymers will be optimized in terms of permeability, selectivity, and stability. In the second task, templated flat AqpZ-ABA membranes will be synthesized and characterized. The project will advance knowledge of transport in hydrophobic nanopores which has great potential for efficient gas and liquid separations and will enhance understanding of protein insertion behavior and transport properties in self-assembled biomimetic supramolecular materials. It will also help develop procedures for 2D crystallization of proteins using templating polymers.Successful development of this new ROM technology may have broad applications beyond water and wastewater treatment, including drug delivery systems, and gas and liquid separations systems in the chemical process industry. There is international collaboration on the project including graduate student education in Switzerland to learn advanced polymer synthesis. Undergraduate students will be involved in the project through the College Summer Research Opportunity program. An effort will be made to recruit minority high school students through the McWest program in Chicago. The PI is also involved with the McWest programs in Chicago lecturing high school students about career opportunities in engineering.

CBET-0828512 Clark水分离工艺越来越多地用于水和废水处理以及医疗、工业和市政应用，如透析、高质量水制备、乙醇浓缩以及果汁和芳香剂浓缩。 反渗透（RO）是一种压力驱动的水分离工艺，其使用受到现有膜的低生产率和用于维持操作压力的高能耗的限制。 本提案的主要目标是开发用于水和废水处理的先进反渗透膜技术。 所提出的研究的总体假设是，可以通过将生物水通道蛋白（水通道蛋白或水通道蛋白）纳入合成聚合物中来开发高效的溶质排斥渗透膜。本研究包括两个主要的研究任务。在第一个任务中，将AqpZ插入阿坝聚合物中将在渗透性、选择性和稳定性方面进行优化。在第二个任务中，模板化的平面AqpZ-ABA膜将被合成和表征。该项目将推进疏水纳米孔中的运输知识，这对有效的气体和液体分离具有巨大的潜力，并将增强对自组装仿生超分子材料中蛋白质插入行为和运输特性的理解。这一新的ROM技术的成功开发可能会在水和废水处理之外有广泛的应用，包括药物输送系统以及化学过程工业中的气体和液体分离系统。该项目有国际合作，包括在瑞士进行研究生教育，以学习先进的聚合物合成。本科生将通过大学暑期研究机会计划参与该项目。将努力通过芝加哥的McWest项目招募少数族裔高中生。PI还参与了芝加哥的McWest项目，向高中生讲授工程方面的职业机会。