Research Module for Organic Chemistry Laboratory Instruction. Parallel Library Synthesis, Stereochemical Synthesis, and Integrated Spectroscopic Analysis

化学(12)明尼苏达州立大学穆尔黑德(MSUM)正在调查将学生研究纳入本科生有机化学实验教学的影响。正在开发一个为期六周的研究性调查模块，供有机化学实验室第二学期使用，每年招收60-70名学生。实验设计、实验的计划和执行以及光谱和色谱数据的分析在很大程度上转移到了学生身上。这个项目的基本目标是：1)提高学生进行相对独立实验的能力；2)使学生进行批判性思维和分析；3)加强研究性仪器与本科化学课程的整合。新的有机化学研究模块涉及一个化学物库的多步骤合成，其中许多以前从未报道过。学生参与目标选择；实验分析、计划和执行；结果分析；动力学、光谱和层析分析；以及化合物库中结构/活性关系的分析。学生获得了在现代化学合成中进行一些最重要的基本有机反应的经验。综合模块还涉及广泛使用现代化学仪器，包括一个新的气相色谱-质谱仪(GC-MS)单元和一个自动制备闪蒸色谱仪单元。这个项目的目标结果包括学生更多地关注学习、探究和发现的过程，而不是获得“正确的答案”，学生成为更好的学习者，以及学生获得更好地理解科学过程的信心。通过对学习过程的拟议改变，预计学生对科学的兴趣和所有权将会增加。此外，学生们还加强了对许多重要化学反应和重要现代化学技术的学习。正在制定的学习材料和教学策略可望转让给其他科学教育工作者实施或改编。正在使用各种评估工具来评估该项目的教育成功。这些课程涉及学生对科学和科学研究的态度和信心，学生在技术领域的学习和能力，以及批判性思维和实验设计技能的发展。GC-MS装置和自动制备闪蒸装置也被用于有机化学实验室的其他部分，以及普通化学、无机化学和分析化学实验室，以及本科生研究项目。密歇根州立大学位于明尼苏达州西部，有大约7500名学生，其中约65%是女性，服务于一个拥有大量美洲原住民人口和大量且不断增长的少数族裔人口(约24%)的地区。该项目的结果以及制定的教材和战略将在MSUM教育界内以及与州和国家层面的其他教育工作者共享。

Chemistry (12)The impact of integrating student research into undergraduate organic chemistrylaboratory instruction is being investigated at Minnesota State University Moorhead (MSUM). A six-week, research-based investigation module is being developed for application in the second semester of organic chemistry laboratory with an enrollment of 60-70 students per year. The responsibility for experimental design, the planning and execution of experiments, and the analysis of spectroscopic and chromatographic data is largely transferred to the student. The fundamental goals of this project are to: 1) enhance the ability of students to conduct relatively independent experiments, 2) engage students in critical thinking and analysis, and 3) enhance the integration of research instrumentation into the undergraduate chemistry curriculum. The new organic chemistry research module involves a multistep synthesis of a library of chemicals, many of which have not been previously reported. Students are involved in target selection; in experimental analysis, planning, and execution; in outcome analysis; in kinetic, spectroscopic, and chromatographic analysis; and in analysis of structure/activity relationships within the library of compounds. Students gain experience in conducting some of the most important fundamental organic reactions in modern chemical synthesis. The integrated module also involves extensive use of modern chemical instrumentation including a new Gas Chromatography-Mass Spectrometry (GC-MS) unit and an automated preparative flash chromatography unit. The targeted outcomes for this project include students focusing more on the process of learning, inquiry, and discovery than on achieving the "right answer," students becoming better learners, and students gaining the confidence to better understand the scientific process. Through the proposed changes in the learning process, students are expected to have an increased interest and ownership in science. In addition, students are enhancing their learning about many important chemical reactions and about important modern chemical techniques. The learning materials and teaching strategies being developed are expected to be transferable for implementation or adaptation by other science educators. A variety of assessment tools are being used to evaluate the educational success of the project. These address student attitudes and confidence toward science and scientific research, student learning and competence in technical areas, and the development of skills in critical thinking and experimental design. The GC-MS unit and the automated preparative flash chromatography unit also are being used in other portions of the organic chemistry laboratories and in laboratories in general chemistry, inorganic chemistry, and analytical chemistry, and in undergraduate student research projects. MSUM, located in western Minnesota, has about 7,500 students, about 65% of whom are women, and serves an area with a substantial Native American population and a substantial and growing minority population (about 24%). The findings of the project and the teaching materials and strategies that are developed will be shared within the MSUM educational community, and with other educators at the state and national level.