Research Module for Organic Chemistry Laboratory Instruction. Parallel Library Synthesis, Stereochemical Synthesis, and Integrated Spectroscopic Analysis

化学（12）明尼苏达州立大学穆尔黑德分校（MSUM）正在研究将学生研究纳入本科有机化学实验室教学的影响。一个为期六周的，以研究为基础的调查模块正在开发中的有机化学实验室的第二学期的应用，每年招收60-70名学生。实验设计，实验的计划和执行以及光谱和色谱数据的分析的责任主要转移到学生身上。该项目的基本目标是：1）提高学生进行相对独立实验的能力，2）让学生进行批判性思维和分析，3）加强研究仪器与本科化学课程的整合。 新的有机化学研究模块涉及化学品库的多步合成，其中许多以前没有报道过。学生参与目标选择;实验分析，规划和执行;结果分析;动力学，光谱和色谱分析;以及化合物库内的结构/活性关系分析。学生获得在现代化学合成中进行一些最重要的基本有机反应的经验。集成模块还涉及现代化学仪器的广泛使用，包括新的气相色谱-质谱（GC-MS）单元和自动制备快速色谱单元。 该项目的目标成果包括学生更多地关注学习、探究和发现的过程，而不是实现“正确答案”，学生成为更好的学习者，学生获得更好地理解科学过程的信心。 通过对学习过程的拟议改革，学生们有望对科学产生更大的兴趣和主人翁精神。此外，学生们正在加强对许多重要的化学反应和重要的现代化学技术的学习。正在开发的学习材料和教学策略有望被其他科学教育工作者用于实施或调整。正在使用各种评估工具来评估该项目在教育方面的成功。这些解决了学生对科学和科学研究的态度和信心，学生在技术领域的学习和能力，以及批判性思维和实验设计技能的发展。 GC-MS单元和自动制备快速色谱单元也被用于有机化学实验室的其他部分和普通化学，无机化学和分析化学实验室以及本科生研究项目。 MSUM位于明尼苏达州西部，拥有约7，500名学生，其中约65%为女性，并为大量美洲原住民人口和大量且不断增长的少数民族人口（约24%）提供服务。该项目的调查结果以及制定的教材和战略将在MSUM教育界以及州和国家一级的其他教育工作者中分享。

Chemistry (12)The impact of integrating student research into undergraduate organic chemistrylaboratory instruction is being investigated at Minnesota State University Moorhead (MSUM). A six-week, research-based investigation module is being developed for application in the second semester of organic chemistry laboratory with an enrollment of 60-70 students per year. The responsibility for experimental design, the planning and execution of experiments, and the analysis of spectroscopic and chromatographic data is largely transferred to the student. The fundamental goals of this project are to: 1) enhance the ability of students to conduct relatively independent experiments, 2) engage students in critical thinking and analysis, and 3) enhance the integration of research instrumentation into the undergraduate chemistry curriculum. The new organic chemistry research module involves a multistep synthesis of a library of chemicals, many of which have not been previously reported. Students are involved in target selection; in experimental analysis, planning, and execution; in outcome analysis; in kinetic, spectroscopic, and chromatographic analysis; and in analysis of structure/activity relationships within the library of compounds. Students gain experience in conducting some of the most important fundamental organic reactions in modern chemical synthesis. The integrated module also involves extensive use of modern chemical instrumentation including a new Gas Chromatography-Mass Spectrometry (GC-MS) unit and an automated preparative flash chromatography unit. The targeted outcomes for this project include students focusing more on the process of learning, inquiry, and discovery than on achieving the "right answer," students becoming better learners, and students gaining the confidence to better understand the scientific process. Through the proposed changes in the learning process, students are expected to have an increased interest and ownership in science. In addition, students are enhancing their learning about many important chemical reactions and about important modern chemical techniques. The learning materials and teaching strategies being developed are expected to be transferable for implementation or adaptation by other science educators. A variety of assessment tools are being used to evaluate the educational success of the project. These address student attitudes and confidence toward science and scientific research, student learning and competence in technical areas, and the development of skills in critical thinking and experimental design. The GC-MS unit and the automated preparative flash chromatography unit also are being used in other portions of the organic chemistry laboratories and in laboratories in general chemistry, inorganic chemistry, and analytical chemistry, and in undergraduate student research projects. MSUM, located in western Minnesota, has about 7,500 students, about 65% of whom are women, and serves an area with a substantial Native American population and a substantial and growing minority population (about 24%). The findings of the project and the teaching materials and strategies that are developed will be shared within the MSUM educational community, and with other educators at the state and national level.