Research Module for Organic Chemistry Laboratory Instruction. Parallel Library Synthesis, Stereochemical Synthesis, and Integrated Spectroscopic Analysis

明尼苏达州立大学摩尔黑德分校（MSUM）正在调查将学生研究纳入本科有机化学实验室教学的影响。有机化学实验室下学期采用为期6周的研究型调查模块，每年招收60-70名学生。实验设计，计划和执行实验，以及光谱和色谱数据分析的责任大部分转移给学生。该项目的基本目标是：1)提高学生进行相对独立实验的能力；2)培养学生批判性思维和分析能力；3)加强研究仪器与本科化学课程的整合。新的有机化学研究模块涉及化学物质库的多步合成，其中许多以前没有报道过。学生参与目标选择；在实验分析、计划和执行方面；结果分析；在动力学、光谱和色谱分析方面；并对化合物库中的结构/活性关系进行分析。学生将获得在现代化学合成中进行一些最重要的基本有机反应的经验。集成模块还涉及广泛使用现代化学仪器，包括一个新的气相色谱-质谱（GC-MS）单元和一个自动制备闪蒸色谱单元。该项目的目标成果包括学生更关注学习、探究和发现的过程，而不是获得“正确答案”，学生成为更好的学习者，学生获得更好地理解科学过程的信心。通过在学习过程中提出的变化，期望学生对科学有更大的兴趣和所有权。此外，学生们正在加强对许多重要化学反应和重要现代化学技术的学习。正在制定的学习材料和教学策略预计可被其他科学教育者转移，以供实施或调整。各种各样的评估工具被用来评估项目的教育成功。这些内容涉及学生对科学和科学研究的态度和信心，学生在技术领域的学习和能力，以及批判性思维和实验设计技能的发展。GC-MS单元和自动制备快闪色谱单元也被用于有机化学实验室的其他部分、普通化学、无机化学和分析化学实验室以及本科生研究项目中。MSUM位于明尼苏达州西部，拥有约7500名学生，其中约65%是女性，服务于一个拥有大量美洲原住民人口和大量且不断增长的少数民族人口（约24%）的地区。该项目的研究成果以及制定的教学材料和策略将在MSUM教育界分享，并与州和国家一级的其他教育工作者分享。

Chemistry (12)The impact of integrating student research into undergraduate organic chemistrylaboratory instruction is being investigated at Minnesota State University Moorhead (MSUM). A six-week, research-based investigation module is being developed for application in the second semester of organic chemistry laboratory with an enrollment of 60-70 students per year. The responsibility for experimental design, the planning and execution of experiments, and the analysis of spectroscopic and chromatographic data is largely transferred to the student. The fundamental goals of this project are to: 1) enhance the ability of students to conduct relatively independent experiments, 2) engage students in critical thinking and analysis, and 3) enhance the integration of research instrumentation into the undergraduate chemistry curriculum. The new organic chemistry research module involves a multistep synthesis of a library of chemicals, many of which have not been previously reported. Students are involved in target selection; in experimental analysis, planning, and execution; in outcome analysis; in kinetic, spectroscopic, and chromatographic analysis; and in analysis of structure/activity relationships within the library of compounds. Students gain experience in conducting some of the most important fundamental organic reactions in modern chemical synthesis. The integrated module also involves extensive use of modern chemical instrumentation including a new Gas Chromatography-Mass Spectrometry (GC-MS) unit and an automated preparative flash chromatography unit. The targeted outcomes for this project include students focusing more on the process of learning, inquiry, and discovery than on achieving the "right answer," students becoming better learners, and students gaining the confidence to better understand the scientific process. Through the proposed changes in the learning process, students are expected to have an increased interest and ownership in science. In addition, students are enhancing their learning about many important chemical reactions and about important modern chemical techniques. The learning materials and teaching strategies being developed are expected to be transferable for implementation or adaptation by other science educators. A variety of assessment tools are being used to evaluate the educational success of the project. These address student attitudes and confidence toward science and scientific research, student learning and competence in technical areas, and the development of skills in critical thinking and experimental design. The GC-MS unit and the automated preparative flash chromatography unit also are being used in other portions of the organic chemistry laboratories and in laboratories in general chemistry, inorganic chemistry, and analytical chemistry, and in undergraduate student research projects. MSUM, located in western Minnesota, has about 7,500 students, about 65% of whom are women, and serves an area with a substantial Native American population and a substantial and growing minority population (about 24%). The findings of the project and the teaching materials and strategies that are developed will be shared within the MSUM educational community, and with other educators at the state and national level.