SBIR Phase I: Innovation for an Easy to Use Clinical a/LCI System for in Vivo Detection of Precancer

SBIR 第一阶段：创新用于癌前病变体内检测的易于使用的临床 a/LCI 系统

• 批准号: 0839481
• 负责人: William Brown
• 金额: --
• 依托单位: Oncoscope, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0839481&HistoricalAwards=false
• 关键词: SBIR; Phase; Innovation; Easy; Use

This Small Business Innovation Research (SBIR) Phase I project seeks to develop new clinical instrument for detecting early stage cancer in human epithelial tissues, the origin of most cancers. The instrument is based on a novel optical spectroscopic technology which is capable of providing information about cell nuclear morphology in vivo without the need to physically remove tissue. Preliminary experiments have shown a very high level of sensitivity and specificity when compared to pathological evaluation of tissue. The ability to quickly and accurately examine many tissue sites translates to significant commercial potential in clinical and research applications. The proposed research will enable clinical usage by simplifying instrument design and providing a robust, well calibrated fiber probe. The new instrumentation design will be validated with tissue phantoms experiments and in vivo measurements.The broader impacts of this research include benefits to society, education and technology development. The proposed optical system will benefit society as it has the potential to greatly improve endoscopic screening and surveillance of epithelial tissues for signs of cancer by providing instant feedback on tissue health while avoiding the need for random biopsy. We will enable utilization of this technology in teaching, research, and industry through conference presentations and hardware offerings aimed at the research market. Finally, the proposed technology products has a very high commercialization potential such that successful development will lead to employment of technical staff such as electrical and biomedical engineers.

这个小企业创新研究（SBIR）一期项目旨在开发新的临床仪器，用于检测人类上皮组织中的早期癌症，这是大多数癌症的起源。该仪器基于一种新颖的光学光谱技术，该技术能够在不需要物理去除组织的情况下提供有关体内细胞核形态的信息。初步实验表明，与病理组织评价相比，该方法具有很高的敏感性和特异性。快速准确地检查许多组织部位的能力在临床和研究应用中具有重要的商业潜力。拟议的研究将通过简化仪器设计和提供坚固、校准良好的纤维探针来实现临床应用。新的仪器设计将通过组织模型实验和体内测量进行验证。这项研究的广泛影响包括对社会、教育和技术发展的好处。提出的光学系统将造福社会，因为它有可能通过提供组织健康的即时反馈，极大地改善内窥镜筛查和监测上皮组织的癌症迹象，同时避免了随机活检的需要。我们将通过针对研究市场的会议演示和硬件产品，使这项技术能够在教学、研究和工业中得到利用。最后，拟议的技术产品具有很高的商业化潜力，因此成功的开发将导致电气和生物医学工程师等技术人员的就业。