SBIR Phase II: Extended depth imaging with optical coherence tomography (OCT)

SBIR 第二阶段：使用光学相干断层扫描 (OCT) 进行扩展深度成像

• 批准号: 2025988
• 负责人: William Brown
• 金额: $ 99.93万
• 依托单位: Lumedica, Inc
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2025988&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Extended; depth

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is in the development of new optical imaging techniques for evaluating the health of skin, teeth and gums. Optical imaging uses light instead of X-rays to produce detailed images of tissues. It has not yet been widely applied for dental and dermatology applications because the light does not penetrate deeply enough into tissues to be useful, and these devices are prohibitively expensive to manufacture. This project will develop a a new imaging scheme that allows deeper penetration into tissues, providing more useful diagnostic information; and with current 3D manufacturing techniques, it could cost roughly ten times less than the current alternatives. This technology will enable new safe, affordable imaging processes.This Small Business Innovation Research (SBIR) Phase II project advances translation of a novel optical technique, dual axis deep imaging optical coherence tomography (OCT), for clinical imaging of skin and teeth. Translation of OCT is advanced for retinal imaging but has not enjoyed the same success in other applications. This project will create new instruments for dentistry and dermatology by demonstrating: 1) how dual axis OCT can penetrate more deeply in biological tissues using instruments designed for each application; and 2) the economic feasibility using 3D manufacturing and system design.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第二阶段项目的更广泛的影响/商业潜力是开发新的光学成像技术，用于评估皮肤，牙齿和牙龈的健康。光学成像使用光而不是X射线来产生组织的详细图像。它还没有被广泛应用于牙科和皮肤病学应用，因为光不能足够深地穿透到组织中以发挥作用，并且这些设备的制造成本过高。该项目将开发一种新的成像方案，允许更深入地渗透到组织中，提供更有用的诊断信息;并且使用当前的3D制造技术，它的成本可能比当前的替代品低大约10倍。这项技术将使新的安全，负担得起的成像过程。这个小企业创新研究（SBIR）第二阶段项目推进翻译的一种新的光学技术，双轴深度成像光学相干断层扫描（OCT），用于皮肤和牙齿的临床成像。OCT的翻译对于视网膜成像来说是先进的，但在其他应用中并没有取得同样的成功。 该项目将通过展示：1）双轴OCT如何使用为每种应用设计的仪器更深入地穿透生物组织;和2）该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查进行评估，被认为值得支持的搜索.