SBIR Phase I: MEMS Electromagnetic Pump

SBIR 第一阶段：MEMS 电磁泵

• 批准号: 0839747
• 负责人: Jaquelin Spong
• 金额: $ 10万
• 依托单位: Innovative Micro Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0839747&HistoricalAwards=false
• 关键词: SBIR; Phase; MEMS; Electromagnetic; Pump

This Small Business Innovation Research (SBIR) Phase I project will prototype a MEMS-based electromagnetic pump for small, controlled or continuous delivery of a drug. In contrast to other designs for micropumps, the MEMS pump is configured to move in the plane of the substrate on which it is built, allowing it to have relatively complex shape, high speed and large throw. This planar configuration also allows relatively large particles to be pumped through the microfluidic system, such that particle-based slurries can also be delivered in therapeutic doses. The MEMS in-plane electromagnetic pump has better performance than other pumping mechanisms such as piezoelectric, in terms of voltage requirements, speed, pumping force and manufacturability. The broader impacts of this research are that the pump described here may be used to produce a very small pumping system appropriate for use in an adhesive patch worn on the skin to deliver, for example, insulin in small, adjustable dosages. Coupling the pump to a glucose monitoring system may eventually form an artificial pancreas to deliver insulin on a controlled, continuous basis. Such tight control of blood glucose levels could mitigate the large number of life threatening or at least life limiting health consequences of diabetes. The pump may also be coupled to other sensors, to administer controlled volumes of other substances, or in response to the detection of other biochemical signals, for example in the treatment of cardiovascular disease, pain, chronic pain, cancer, AIDS, neurological diseases, Alzheimer's Disease, Hepatitis, or Parkinson's Disease.

该小型企业创新研究（SBIR）第一阶段项目将开发一种基于MEMS的电磁泵原型，用于小型、可控或连续的药物输送。与微型泵的其他设计相比，MEMS泵被配置为在其上构建有MEMS泵的基板的平面中移动，从而允许MEMS泵具有相对复杂的形状、高速度和大行程。该平面构造还允许相对大的颗粒被泵送通过微流体系统，使得基于颗粒的浆料也可以以治疗剂量递送。MEMS面内电磁泵在电压要求、速度、泵送力和可制造性方面比压电等其他泵送机构具有更好的性能。这项研究的更广泛影响是，这里描述的泵可用于生产非常小的泵送系统，适用于佩戴在皮肤上的粘合剂贴片，以输送例如小剂量、可调节剂量的胰岛素。将泵耦合到葡萄糖监测系统可以最终形成人工胰腺，以在受控的连续基础上输送胰岛素。血糖水平的这种严格控制可以减轻糖尿病的大量威胁生命或至少限制生命的健康后果。泵还可以耦合到其它传感器，以施用受控体积的其它物质，或者响应于其它生化信号的检测，例如在心血管疾病、疼痛、慢性疼痛、癌症、AIDS、神经疾病、阿尔茨海默病、肝炎或帕金森病的治疗中。