SBIR Phase II: Closed-loop control of MEMS deformable mirror for two-photon microscopy

SBIR 第二阶段：双光子显微镜 MEMS 可变形镜的闭环控制

• 批准号: 1831287
• 负责人: Christopher Arrasmith
• 金额: $ 74.96万
• 依托单位: Revibro Optics LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831287&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Closed; loop

This Small Business Innovation Research (SBIR) Phase II project will enable video-rate three-dimensional (3D) imaging within two-photon microscopes (2PMs) by developing novel deformable membrane mirror (DMM) technology for fast, precise focus control. As a subset of laser scanning microscopes (LSMs), 2PMs achieve very high spatial resolution by using a focused, high-power laser beam to excite fluorescence via the simultaneous absorption of two low-energy infrared photons to stimulate emission in the visible spectrum. Because of the increased resolution, and increased penetration of infrared light into tissue compared with other LSM methods, 2PMs have become widely accepted for use in the life sciences, specifically for neuroscience. The DMM technology developed for this project will address the $165 million 2PM market by delivering an electrically tunable optic capable of simultaneously controlling focus and aberrations while operating an order of magnitude faster than competitive technologies. The 3D imaging capabilities enabled by this technology will propel new research in the field of neuroscience aimed at solving widespread, chronic medical problems like stroke and Alzheimer's disease. Once the 2PM entry market is addressed, this technology will be refined to address the much larger $5.8 billion 3D laser printing market. During the Phase I project, new mirror coatings were developed to handle the high-power lasers used in 2PMs. With the core DMM technology in place, this Phase II project is aimed primarily at control of mirror actuation and shape for reliable use in 2PMs. The first objective of this Phase II project will develop electronics for robust control of mirror actuation and shape. Objective two will center on refining the core DMM technology and fabrication methods to enable position sensing of the membrane and improve mirror stroke to satisfy customers in 2PM markets. The final objective will involve the creation of optical and mechanical assemblies and modules for incorporating the DMM technology into key microscopes. The result of this Phase II will be a market-ready DMM product with active focus control to address the growing 2PM market.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小型企业创新研究 (SBIR) 第二阶段项目将通过开发新型可变形膜镜 (DMM) 技术来实现快速、精确的焦点控制，从而在双光子显微镜 (2PM) 内实现视频速率三维 (3D) 成像。作为激光扫描显微镜 (LSM) 的一个子集，2PM 通过使用聚焦的高功率激光束通过同时吸收两个低能量红外光子来激发可见光谱中的发射来激发荧光，从而实现非常高的空间分辨率。与其他 LSM 方法相比，由于分辨率更高，红外光对组织的穿透力更强，2PM 已被广泛接受用于生命科学，特别是神经科学。为该项目开发的数字万用表技术将通过提供能够同时控制焦点和像差的电可调光学器件来满足价值 1.65 亿美元的 2PM 市场的需求，同时运行速度比竞争技术快一个数量级。该技术实现的 3D 成像功能将推动神经科学领域的新研究，旨在解决中风和阿尔茨海默病等广泛的慢性医疗问题。一旦 2PM 入门市场得到解决，这项技术将得到完善，以应对规模大得多的 58 亿美元 3D 激光打印市场。在第一阶段项目中，开发了新的镜面涂层来处理 2PM 中使用的高功率激光器。凭借核心 DMM 技术的到位，该第二阶段项目的主要目标是控制反射镜驱动和形状，以便在 2PM 中可靠使用。该第二阶段项目的第一个目标是开发用于对镜子驱动和形状进行稳健控制的电子设备。目标二将集中于完善核心 DMM 技术和制造方法，以实现薄膜的位置感测并改善镜面行程，以满足 2PM 市场的客户需求。最终目标将涉及创建光学和机械组件以及模块，以将数字万用表技术整合到关键显微镜中。第二阶段的成果将是一款可上市的 DMM 产品，具有主动聚焦控制功能，可满足不断增长的 2PM 市场的需求。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。