SBIR Phase II: Closed-loop control of MEMS deformable mirror for two-photon microscopy

SBIR 第二阶段：双光子显微镜 MEMS 可变形镜的闭环控制

• 批准号: 1831287
• 负责人: Christopher Arrasmith
• 金额: $ 74.96万
• 依托单位: Revibro Optics LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831287&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Closed; loop

This Small Business Innovation Research (SBIR) Phase II project will enable video-rate three-dimensional (3D) imaging within two-photon microscopes (2PMs) by developing novel deformable membrane mirror (DMM) technology for fast, precise focus control. As a subset of laser scanning microscopes (LSMs), 2PMs achieve very high spatial resolution by using a focused, high-power laser beam to excite fluorescence via the simultaneous absorption of two low-energy infrared photons to stimulate emission in the visible spectrum. Because of the increased resolution, and increased penetration of infrared light into tissue compared with other LSM methods, 2PMs have become widely accepted for use in the life sciences, specifically for neuroscience. The DMM technology developed for this project will address the $165 million 2PM market by delivering an electrically tunable optic capable of simultaneously controlling focus and aberrations while operating an order of magnitude faster than competitive technologies. The 3D imaging capabilities enabled by this technology will propel new research in the field of neuroscience aimed at solving widespread, chronic medical problems like stroke and Alzheimer's disease. Once the 2PM entry market is addressed, this technology will be refined to address the much larger $5.8 billion 3D laser printing market. During the Phase I project, new mirror coatings were developed to handle the high-power lasers used in 2PMs. With the core DMM technology in place, this Phase II project is aimed primarily at control of mirror actuation and shape for reliable use in 2PMs. The first objective of this Phase II project will develop electronics for robust control of mirror actuation and shape. Objective two will center on refining the core DMM technology and fabrication methods to enable position sensing of the membrane and improve mirror stroke to satisfy customers in 2PM markets. The final objective will involve the creation of optical and mechanical assemblies and modules for incorporating the DMM technology into key microscopes. The result of this Phase II will be a market-ready DMM product with active focus control to address the growing 2PM market.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业创新研究(SBIR)第二阶段项目将通过开发用于快速、精确焦点控制的新型可变形膜镜(DMM)技术，在双光子显微镜(2PM)内实现视频率三维(3D)成像。作为激光扫描显微镜(LSM)的一个子集，2PM利用聚焦的高功率激光束同时吸收两个低能量的红外光子来激发荧光，从而在可见光光谱中激发发射，从而实现非常高的空间分辨率。由于与其他LSM方法相比，2PM具有更高的分辨率和更强的红外线对组织的穿透力，2PM已被广泛用于生命科学，特别是神经科学。为该项目开发的数字多用表技术将满足1.65亿美元的2 PM市场，提供一种能够同时控制聚焦和像差的电子可调光学器件，同时运行速度比竞争对手的技术快一个数量级。这项技术带来的3D成像能力将推动神经科学领域的新研究，旨在解决中风和阿尔茨海默病等普遍存在的慢性医学问题。一旦2 PM进入市场得到解决，这项技术将得到改进，以满足规模更大、价值58亿美元的3D激光打印市场。在第一阶段的项目中，开发了新的镜面涂层来处理2PM中使用的高功率激光器。随着DMM核心技术的到位，这个二期项目的主要目标是控制反射镜的驱动和形状，以便在2PM中可靠地使用。这个第二阶段项目的第一个目标是开发用于稳健控制反射镜驱动和形状的电子设备。目标二将集中在改进核心DMM技术和制造方法，以实现薄膜的位置传感和改进镜面行程，以满足2 PM市场的客户。最终目标将涉及创造光学和机械组件以及将数字万用表技术纳入关键显微镜的模块。第二阶段的结果将是一款具有主动聚焦控制的市场就绪的数字万用表产品，以满足不断增长的下午2点市场。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。