CRIF: MU - Acquisition of a Cyber-Enabled Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometer

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。获得化学研究仪器与设备协会颁发的奖项：多用户项目（CRIF:MU），来自德雷塞尔大学的Lynn S. Penn及其同事海峰Ji， Kevin G. Owens， Yen Wei和Jun Zi将获得一台具有后源衰减（PSD）能力的网络矩阵辅助激光解吸/电离飞行时间质谱仪（MALDI/TOF），以提供准确的分子量分布和大的非挥发性分子的平均分子量，并完成肽分析。该仪器将用于了解聚合物刷作为选择性扩散屏障的尺寸选择标准，单分散电活性聚苯胺的合成，控制尺寸的树突的合成和研究，特定化学位点的识别和表征所选蛋白质的络合，用于超薄薄膜形成的聚电解质的合成。设计共聚物的合成，在碳纳米管上形成可控的两相微观结构。maldi - tof质谱法是在非常大的分子上获得准确分子量的首选技术，具有极高的灵敏度。因此，使用MALDI-TOF质谱仪已成为一种标准技术，特别是在涉及生物分子和聚合物的研究中。这项研究将在许多领域产生重大影响，特别是化学、材料和生物化学。该仪器将成为教学和研究的一个组成部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), Lynn S. Penn and colleagues Haifeng Ji, Kevin G. Owens, Yen Wei, and Jun Zi from Drexel University will acquire a acquire a cyber-enabled matrix assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI/TOF) with post source decay (PSD) capabilities to provide accurate determinations of molecular weight distribution and average molecular weights of large, nonvolatile molecules, and to accomplish peptide analyses. The instrument will be used for understanding size selection criteria by which polymer brushes act as selective barriers to diffusion, synthesis of monodisperse electroactive polyanilines, synthesis and study of dendrons of controlled size, identification and characterization of the specific chemical sites involved in complexation of selected proteins, synthesis of polyelectrolytes for use in layer-bylayer formation of ultra-thin films, and synthesis of designed copolymers for creation of controlled two-phase microstructures on carbon nanotubes.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules and polymers. This research will have a significant impact in a number of areas, especially chemistry, materials and biochemistry. This instrument will be an integral part of teaching as well as research.