CRIF: MU - Acquisition of a Cyber-Enabled Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometer

CRIF：MU - 采购网络支持的基质辅助激光解吸/电离 (MALDI) 质谱仪

• 批准号: 0840273
• 负责人: Lynn Penn
• 金额: $ 24.98万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840273&HistoricalAwards=false
• 关键词: CRIF; MU; Acquisition; Cyber; Enabled

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), Lynn S. Penn and colleagues Haifeng Ji, Kevin G. Owens, Yen Wei, and Jun Zi from Drexel University will acquire a acquire a cyber-enabled matrix assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI/TOF) with post source decay (PSD) capabilities to provide accurate determinations of molecular weight distribution and average molecular weights of large, nonvolatile molecules, and to accomplish peptide analyses. The instrument will be used for understanding size selection criteria by which polymer brushes act as selective barriers to diffusion, synthesis of monodisperse electroactive polyanilines, synthesis and study of dendrons of controlled size, identification and characterization of the specific chemical sites involved in complexation of selected proteins, synthesis of polyelectrolytes for use in layer-bylayer formation of ultra-thin films, and synthesis of designed copolymers for creation of controlled two-phase microstructures on carbon nanotubes.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules and polymers. This research will have a significant impact in a number of areas, especially chemistry, materials and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。Penn及其同事Haifeng Ji，Kevin G.来自德雷克塞尔大学的Owens、Yen Wei和Jun Zi将获得一台网络化基质辅助激光解吸/电离飞行时间质谱仪（MALDI/TOF），该质谱仪具有源后衰减（PSD）功能，可精确测定大的非挥发性分子的分子量分布和平均分子量，并完成肽分析。该仪器将用于理解聚合物刷作为扩散选择性屏障的尺寸选择标准，单分散电活性聚苯胺的合成，可控尺寸的树枝状分子的合成和研究，所选蛋白质络合中涉及的特定化学位点的鉴定和表征，用于超薄膜逐层形成的聚电解质的合成，和合成设计的共聚物，用于在碳纳米管上产生受控的两相微结构。MALDI-TOF-质谱是获得非常大分子的精确分子量的首选技术，具有极高的灵敏度。因此，MALDI-TOF质谱仪的使用已成为标准技术，特别是在涉及生物分子和聚合物的研究中。这项研究将在许多领域产生重大影响，特别是化学，材料和生物化学。该仪器将成为教学和研究的一个组成部分。