Collaborative Research: Acquisition of a 400 MHz NMR at the University of Southern California

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在化学研究仪器和设施：多用户计划（CRIF:MU）的支持下，南加州大学（USC）化学系和加州州立大学富勒顿分校（CSUF）将合作开发一台400 MHz核磁共振（NMR）光谱仪的采集和远程控制网络。它将用于各种各样的研究项目，支持结构，反应和分析研究，例如：1)无机纳米晶体的新合成路线；2)有机化学和有机金属化学合成新方法的发展；3)生物学上重要的有机磷化合物的研究；4)新的合成方法和生物活性分子的合成；5)新型RNA结合肽的设计。多核核磁共振波谱是当今化学分析和表征的关键工具。光谱使研究人员能够跟踪化学反应的进展，识别未知物质，并通过检测原子的核自旋特性产生的能级之间的转换，提供从小分子到大蛋白质等物种的原子排列和结构的信息。该仪器将支持未来科学家的教育，从本科到研究生，再到博士后研究助理。它将用于USC和CSUF的化学和生物化学学生的实验课程。将开发网络基础设施，用于远程控制自动进样器仪器，以及通过基于web的系统远程访问仪器的数据收集/分析。一门实用的核磁共振方法课程将在南加州大学和CSUF联合开发，以培训学生使用核磁共振光谱仪。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Departments of Chemistry at the University of Southern California (USC) and California State University - Fullerton (CSUF) will collaborate on the acquisition and remote control cyber enabling of a 400 MHz nuclear magnetic resonance (NMR) spectrometer to be housed at USC. It will be employed in a wide variety of research projects, supporting structural, reaction, and analytical studies such as 1) new synthetic routes to inorganic nanocrystals; 2) the development of new synthetic methods in organic and organometallic chemistry; 3) studies of biologically important organophosphorus compounds; 4) new synthetic methods and synthesis of bioactive molecules; and 5) the design of novel RNA binding peptides. Multinuclear NMR spectroscopy is a key analysis and characterization tool in chemistry today. The spectra enable researchers to track the progress of chemical reactions, identify unknown substances and provide information on the atomic arrangement and structures in species ranging from small molecules to large proteins by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This instrument will support the education of future scientists at levels from undergraduate, to graduate student, to postdoctoral research associate. It will be used in lab courses for both chemistry and biochemistry students at USC and CSUF. Cyber infrastructure will be developed for both the remote control of the autosampler enabled instrument, as well as remote access for data collection/analysis from the instrument with a web based system. A practical NMR methods course will be developed jointly at USC and CSUF to train students in the use of the NMR spectrometer.