CRIF:MU Acquisition of Cyber-Enabled X/Q-band CW EPR Spectrometer for Use in Research and Education

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。根据化学研究仪器和设施多用户计划（CRIF:MU）的这份合同，北卡罗来纳州立大学的Morteza G. Khaledi教授和同事Alex I. Smirnov和Tatyana I. Smirnova将获得一台网络支持的X/ q波段连续波EPR光谱仪。将受益于该仪器的研究项目包括：1)双基配体过渡金属配合物的结构性质关系；2)利用先进的自旋标记EPR方法研究生物分子的构象；3)开发用于膜蛋白生物芯片的新型杂化纳米材料；4)合成具有独特电子性质的多功能杂化结构，并开发分子水平策略来阐明低三维框架的形成原理；5)可逆加成碎片转移（RAFT）聚合动力学在DNA生物传感中的应用研究；6)了解过氧化氢酶-过氧化物酶（KatG）的功能机制及其独特的含非天然氨基酸的模型配合物；7)开发脱氢过氧化物酶作为生物修复工具；8)手性聚合物与生物膜的相互作用；9)探索已知无机含量最高的金属液晶的磁性和氧化还原特性；10)研究有机质对土壤系统中磷酸铁还原的影响。EPR光谱仪产生分子和分子电子结构的信息。它也可以用来获得自由基的寿命和特性的信息，自由基是肿瘤生长和/或各种化学反应的起始所必需的短命物种。这些研究将在许多领域产生影响，从化学到材料和生物化学。该仪器将成为教学和研究的一个组成部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities Multiuser Program (CRIF:MU), Professor Morteza G. Khaledi and colleagues Alex I. Smirnov and Tatyana I. Smirnova from North Carolina State University will acquire a cyber-enabled X/Q-band continuous-wave EPR spectrometer. Research projects that will benefit from this instrument include: 1) structure property relationships in transition metal complexes of biradical ligands; 2) investigation of conformations of biomolecules by advanced spin-labeling EPR methods; 3) developing new hybrid nanomaterials for membrane protein biochips; 4) synthesis of multifunctional hybrid structures with unique electronic properties and development of molecular-level strategies for elucidating the principles for the formation of low- and three-dimensional frameworks; 5) reversible addition fragmentation transfer (RAFT) polymerization kinetic studies in applications for DNA biosensing; 6) understanding the mechanism of catalase-peroxidase (KatG) function and its unique model complexes containing unnatural amino acids; 7) development of dehaloperoxidase as a tool for bioremediation; 8) interaction of chiral polymers with biological membranes; 9) probing the magnetic and redox properties of metallotropic liquid crystals with the highest known inorganic content, and 10) investigating the impact of organic matter on the reduction of iron phosphates in soil systems.An EPR spectrometer yields information on the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes and identities of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, from chemistry to materials and biological chemistry. This instrument will be an integral part of teaching as well as research.