CRIF:MU Acquisition of Cyber-Enabled X/Q-band CW EPR Spectrometer for Use in Research and Education

该奖项根据 2009 年美国复苏和再投资法案（公法 111-5）提供资金。北卡罗来纳州立大学的 Morteza G. Khaledi 教授及其同事 Alex I. Smirnov 和 Tatyana I. Smirnova 将获得化学研究仪器和设施多用户计划 (CRIF:MU) 授予的这一奖项，从而获得一台网络支持的 X/Q 波段连续波 EPR 光谱仪。 受益于该仪器的研究项目包括：1）双自由基配体过渡金属配合物的结构性质关系； 2）通过先进的自旋标记EPR方法研究生物分子的构象； 3）开发用于膜蛋白生物芯片的新型杂化纳米材料； 4）合成具有独特电子特性的多功能杂化结构，并开发分子水平策略来阐明低维和三维框架的形成原理； 5）DNA生物传感应用中的可逆加成片段转移（RAFT）聚合动力学研究； 6）了解过氧化氢酶-过氧化物酶（KatG）的功能机制及其独特的含有非天然氨基酸的模型复合物； 7）开发脱卤过氧化物酶作为生物修复工具； 8）手性聚合物与生物膜的相互作用； 9) 探索已知无机含量最高的金属致液晶的磁性和氧化还原性质，10) 研究有机物对土壤系统中磷酸铁还原的影响。EPR 光谱仪可提供有关分子的分子和电子结构的信息。它还可用于获取有关自由​​基、短命物质的寿命和身份的信息，这些物质通常对于肿瘤生长和/或各种化学反应的启动至关重要。这些研究将对从化学到材料和生物化学的许多领域产生影响。该仪器将成为教学和研究不可或缺的一部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities Multiuser Program (CRIF:MU), Professor Morteza G. Khaledi and colleagues Alex I. Smirnov and Tatyana I. Smirnova from North Carolina State University will acquire a cyber-enabled X/Q-band continuous-wave EPR spectrometer. Research projects that will benefit from this instrument include: 1) structure property relationships in transition metal complexes of biradical ligands; 2) investigation of conformations of biomolecules by advanced spin-labeling EPR methods; 3) developing new hybrid nanomaterials for membrane protein biochips; 4) synthesis of multifunctional hybrid structures with unique electronic properties and development of molecular-level strategies for elucidating the principles for the formation of low- and three-dimensional frameworks; 5) reversible addition fragmentation transfer (RAFT) polymerization kinetic studies in applications for DNA biosensing; 6) understanding the mechanism of catalase-peroxidase (KatG) function and its unique model complexes containing unnatural amino acids; 7) development of dehaloperoxidase as a tool for bioremediation; 8) interaction of chiral polymers with biological membranes; 9) probing the magnetic and redox properties of metallotropic liquid crystals with the highest known inorganic content, and 10) investigating the impact of organic matter on the reduction of iron phosphates in soil systems.An EPR spectrometer yields information on the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes and identities of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, from chemistry to materials and biological chemistry. This instrument will be an integral part of teaching as well as research.