CRIF:MU Acquisition of Cyber-Enabled X/Q-band CW EPR Spectrometer for Use in Research and Education

CRIF:MU 收购网络支持的 X/Q 波段 CW EPR 光谱仪用于研究和教育

• 批准号: 0840501
• 负责人: Morteza Khaledi
• 金额: $ 49.91万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840501&HistoricalAwards=false
• 关键词: CRIF; MU; Acquisition; Cyber; Enabled

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities Multiuser Program (CRIF:MU), Professor Morteza G. Khaledi and colleagues Alex I. Smirnov and Tatyana I. Smirnova from North Carolina State University will acquire a cyber-enabled X/Q-band continuous-wave EPR spectrometer. Research projects that will benefit from this instrument include: 1) structure property relationships in transition metal complexes of biradical ligands; 2) investigation of conformations of biomolecules by advanced spin-labeling EPR methods; 3) developing new hybrid nanomaterials for membrane protein biochips; 4) synthesis of multifunctional hybrid structures with unique electronic properties and development of molecular-level strategies for elucidating the principles for the formation of low- and three-dimensional frameworks; 5) reversible addition fragmentation transfer (RAFT) polymerization kinetic studies in applications for DNA biosensing; 6) understanding the mechanism of catalase-peroxidase (KatG) function and its unique model complexes containing unnatural amino acids; 7) development of dehaloperoxidase as a tool for bioremediation; 8) interaction of chiral polymers with biological membranes; 9) probing the magnetic and redox properties of metallotropic liquid crystals with the highest known inorganic content, and 10) investigating the impact of organic matter on the reduction of iron phosphates in soil systems.An EPR spectrometer yields information on the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes and identities of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, from chemistry to materials and biological chemistry. This instrument will be an integral part of teaching as well as research.

北卡罗来纳州立大学的Morteza G.Khaledi教授及其同事Alex I.Smirnov和Tatana I.Smirnova将获得一台联网X/Q波段连续波EPR光谱仪。将受益于该仪器的研究项目包括：1)双自由基配体过渡金属络合物的结构性质关系；2)用先进的自旋标记EPR方法研究生物分子的构象；3)开发用于膜蛋白生物芯片的新型杂化纳米材料；4)合成具有独特电子性质的多功能杂化结构，并开发分子水平的策略，以阐明低和三维骨架的形成原理；5)可逆加成裂解转移(RAFT)聚合动力学研究在DNA生物传感中的应用；6)了解过氧化氢酶-过氧化物酶(KatG)的作用机理及其含有非天然氨基酸的独特模型络合物；7)开发脱氢过氧化物酶作为生物修复的工具；8)手性聚合物与生物膜的相互作用；9)探索已知无机含量最高的金属液晶的磁性和氧化还原性质；10)研究有机物对土壤系统中磷酸铁还原的影响。EPR光谱仪提供关于分子和电子结构的信息。它还可以用来获得有关自由基的寿命和身份的信息，自由基是一种寿命较短的物种，通常对启动肿瘤生长和/或各种化学反应至关重要。这些研究将在许多领域产生影响，从化学到材料和生物化学。该仪器将成为教学和研究不可或缺的一部分。