Mechanics and dynamics of biological adhesion (A08)

细胞粘附是特定短程吸引力、中程排斥相互作用和长程弹性相互作用之间竞争的结果。本项目的目标是解决这些不同的长度尺度，并研究在接触区形成的粘合键簇的形成，强度和动力学。特别是，通过采用模型系统的层次结构，我们将研究如何动态强度的个人粘附键，排斥分子的存在和弹性特性，以及内部和外部的信封（细胞皮层）的力量影响这个最佳的集群大小与最大的寿命或强度。

Cellular adhesion is the result of a competition between specific short-range attractive forces, medium- range repulsive interactions and long-range elastic interactions. The goal of this project is to address these different length scales and to investigate the formation, strength and dynamics of clusters of adhesion bonds that form in the contact zone. Particularly, by employing a hierarchy of model systems, we will investigate how the dynamic strength of individual adhesion bonds, the presence of repeller molecules and the elastic properties as well as internal and external forces of the envelope (cell cortex) influence this optimal cluster size with the maximum lifetime or strength.