CAREER: The chemistry and biology of halogenated natural products

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。哥伦比亚大学化学系的Scott A. Snyder教授将通过探索新型亲电卤素试剂和代物，为烯烃的不对称卤化开发新方法，获得美国国家科学基金会化学部有机和大分子化学项目颁发的CAREER奖。这些努力的成功将为实现非活化烯烃的不对称卤化以及直接和间接卤化诱导的阳离子环化提供第一种方法。将这些反应添加到合成化学工具箱中，将最终使合成数十种尚未解决的天然产物结构成为可能，这些结构将卤素原子与独特的、基本上未被探索的化学生物学特征结合在一起。它还应该阐明试剂设计和合成策略的原则，这可能有助于解决其他重大挑战。此外，有机和大分子化学项目的支持将使Snyder教授能够利用天然产物合成和反应设计的力量来扩大追求stem职业的学生的数量和多样性。这些努力将集中在高中和本科阶段。首先，Snyder教授将为纽约市当地高中的学生和教师，特别是社会经济多样性高的公立学校的学生和教师提供一个机会，让他们参加一个专门为哥伦比亚大学量身定制的体验访问日，然后有机会在Snyder教授的实验室工作八周。在实验室里，他们将研究一个具有挑战性的化学研究问题，并开发一个可以在未来几年用于学校实验室项目的实验。其次，Snyder教授将为哥伦比亚大学的本科有机化学入门课程创建一个探究式的实验室项目，该项目以天然产物全合成为基础。这一概念旨在使教学课程现代化，更好地将其目标与课堂和实验室环境结合起来，并最好地向本科生说明合成有机化学的真实本质和令人兴奋的地方。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this CAREER award from the Organic and Macromolecular Chemistry Program in the Chemistry Division at the National Science Foundation, Professor Scott A. Snyder of the Department of Chemistry at Columbia University will develop new approaches for the asymmetric halogenation of alkenes by exploring novel classes of electrophilic halogen reagents and surrogates. The success of these efforts will provide the first way to achieve asymmetric halogenation of unactivated olefins as well as direct and indirect halonium-induced cation-pi cyclizations. The addition of these reactions to the synthetic chemistry toolbox would finally make possible the synthesis of dozens of unsolved natural product architectures that possess halogen atoms in combination with unique, and largely unexplored, chemical biology profiles. It should also elucidate principles in reagent design and synthetic strategy that may help to solve other significant challenges. In addition, the support of the Organic and Macromolecular Chemistry Program will enable Professor Snyder to utilize the power of natural products synthesis and reaction design to expand the number and diversity of students pursuing STEM-based careers. These efforts will be focused on both the high school and undergraduate levels. First, Professor Snyder will offer students and teachers from local high schools in the New York City area, particularly public schools with high socioeconomic diversity, an opportunity to participate in a specially tailored experiential visit day at Columbia University, followed by a chance to work in Professor Snyder's laboratory for eight weeks. In the laboratory, they will work on a challenging chemical research problem and develop an experiment that can be utilized in the school's laboratory program for years to come. Second, Professor Snyder will create an inquiry-based laboratory program for Columbia's introductory undergraduate organic chemistry program based on a natural product total synthesis. This concept is meant to modernize the teaching curriculum, better marry its objectives across lecture and laboratory settings, and best illustrate to undergraduates the real nature and excitement of synthetic organic chemistry.