Variation in bacterial genomic mutation rates

细菌基因组突变率的变化

• 批准号: DP0988743
• 负责人: Dr Thomas Ferenci
• 金额: $ 22.84万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-02-27 至 2013-02-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988743
• 关键词: Variation; bacterial; genomic; mutation; rates

Our measurement of global mutation rates will contribute to an understanding of the evolutionary properties of bacteria, the most diverse and successful organisms in the biosphere. Bacterial variation and culture richness contributes not only to ecological processes but also to emerging diseases. The studies will enhance capabilities essential in interpreting the evolution of epidemics and the kinetics of bacterial sweeps in nature. Variation also provides the source material for exploitation of bacterial products such as antibiotics. The results from understanding a complete set of mutational changes through genomic analysis will provide the most direct estimates of variation in evolving bacteria.

我们对全球突变率的测量将有助于理解细菌的进化特性，细菌是生物圈中最多样化和最成功的生物。细菌的变异和培养的丰富性不仅有助于生态过程，而且有助于新出现的疾病。这些研究将增强解释流行病演变和自然界细菌扫掠动力学所必需的能力。变异也为细菌产物如抗生素的开发提供了来源材料。通过基因组分析了解一整套突变变化的结果将为进化细菌的变异提供最直接的估计。