CAREER: Population genetics of Pediculus humanus using coalescent approaches with multi-locus data

职业：使用多位点数据的合并方法进行人类虱子的群体遗传学

• 批准号: 0845392
• 负责人: David Reed
• 金额: $ 93.45万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0845392&HistoricalAwards=false
• 关键词: CAREER; Population; genetics; Pediculus; humanus

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Some of the most compelling questions in evolutionary biology concern the history of our own species. Fossil and genetic data have provided great insights into human evolutionary history, but many important questions remain unanswered. Parasites are closely associated with their hosts, but usually evolve more rapidly, so their genomes may record details of the history of the host that are not recorded clearly in the host's genome. This project examines three lineages of a human parasite to provide new insights into human evolution. The human parasite Pediculus humanus will be collected with the help of colleagues and medical clinicians worldwide. Their genetics will be examined using a suite of modern molecular and analytical methods to explore patterns of human evolution, human migration across the globe, and human demography. Specimen data, images, DNA sequence data, and other research findings will be made available via the Internet. A post-doctoral associate and several graduate students and undergraduates will be trained through participation in the research. The education portion of this project will train undergraduate and graduate students to effectively communicate basic science research findings to broad audiences, training that currently is lacking from most scientific education.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。进化生物学中一些最引人注目的问题涉及我们自己物种的历史。 化石和基因数据为人类进化史提供了深刻的见解，但许多重要的问题仍然没有答案。 寄生虫与宿主关系密切，但通常进化得更快，因此它们的基因组可能会记录宿主基因组中没有清楚记录的宿主历史细节。该项目研究了人类寄生虫的三个谱系，为人类进化提供了新的见解。 人类寄生虫人虱将在世界各地的同事和临床医生的帮助下收集。 他们的遗传学将使用一套现代分子和分析方法进行检查，以探索人类进化的模式，人类在地球仪上的迁移和人类人口统计学。 标本数据、图像、DNA序列数据和其他研究结果将通过互联网提供。 一名博士后助理和几名研究生和本科生将通过参与研究进行培训。该项目的教育部分将培训本科生和研究生，使他们能够有效地向广大受众传播基础科学研究成果，这是目前大多数科学教育所缺乏的培训。