CAREER: Development of a High Efficiency Mass Spectrometry System

职业：开发高效质谱系统

• 批准号: 0847205
• 负责人: Zheng Ouyang
• 金额: $ 55万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847205&HistoricalAwards=false
• 关键词: CAREER; Development; Efficiency; Mass; Spectrometry

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The Analytical & Surface Chemistry Program supports this CAREER award to Professor Zheng Ouyang at Purdue University to explore new instrumentation configurations for mass analysis. Theoretical modeling, numeric simulation, and experimental characterization are used to develop methods and devices for high efficiency ion transfer and mass analysis, challenging the sensitivity limitations of commercial instruments. Instrumentation improvements also target miniaturization of mass spectrometers. Technologies developed will potentially result in significant increases in sensitivity, enabling new approaches to the most challenging problems in biological science, where ultra high sensitivity is required to analyze samples available only in extremely small amounts.This work interfaces with an Analytical Instrumentation Development (AID) Training Program which encourages educational development based on instrumentation prototyping and research. Students with different backgrounds work together to develop prototype instruments based on new analytical technology. Derived instruments are provided to outside end-users for testing and development of applications. The resulting integration of education with research illustrates the transition of learning to real problem solving and provides a test of a new model for training young instrumentalists for analytical instrumentation research. Mechanisms of building a self-sustainable training program will be explored.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。分析与表面化学项目支持普渡大学郑欧阳教授的职业生涯奖，以探索新的质量分析仪器配置。理论建模、数值模拟和实验表征用于开发高效离子传递和质量分析的方法和设备，挑战商用仪器的灵敏度限制。仪器的改进也针对质谱仪的小型化。开发的技术将有可能导致灵敏度的显著提高，为生物科学中最具挑战性的问题提供新的方法，在这些问题中，需要超高的灵敏度来分析极少量的样品。这项工作与分析仪器开发（AID）培训计划相结合，该计划鼓励基于仪器原型和研究的教育发展。来自不同背景的学生合作开发基于新分析技术的原型仪器。衍生仪器提供给外部最终用户用于测试和开发应用程序。由此产生的教育与研究的结合说明了从学习到解决实际问题的转变，并为培养从事分析仪器研究的年轻仪器学家提供了一种新模式的测试。探索建立可持续发展的培训机制。