CAREER: Development of a High Efficiency Mass Spectrometry System

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。分析表面化学计划支持普渡大学郑欧阳教授的职业生涯奖，以探索质量分析的新仪器配置。 理论建模、数值模拟和实验表征用于开发用于高效离子转移和质量分析的方法和设备，挑战商业仪器的灵敏度限制。 仪器的改进也以质谱仪的小型化为目标。 所开发的技术可能会显著提高灵敏度，从而为生物科学中最具挑战性的问题提供新的方法，这些问题需要超高灵敏度来分析极少量的样品。这项工作与分析仪器开发（AID）培训计划相结合，该计划鼓励基于仪器原型和研究的教育发展。 具有不同背景的学生共同开发基于新分析技术的原型仪器。 衍生工具提供给外部最终用户，用于测试和开发应用程序。 由此产生的教育与研究相结合，说明了学习的过渡到真实的问题解决，并提供了一个新的模式，培养年轻的仪器分析仪器的研究测试。 将探讨建立自我维持培训方案的机制。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The Analytical & Surface Chemistry Program supports this CAREER award to Professor Zheng Ouyang at Purdue University to explore new instrumentation configurations for mass analysis. Theoretical modeling, numeric simulation, and experimental characterization are used to develop methods and devices for high efficiency ion transfer and mass analysis, challenging the sensitivity limitations of commercial instruments. Instrumentation improvements also target miniaturization of mass spectrometers. Technologies developed will potentially result in significant increases in sensitivity, enabling new approaches to the most challenging problems in biological science, where ultra high sensitivity is required to analyze samples available only in extremely small amounts.This work interfaces with an Analytical Instrumentation Development (AID) Training Program which encourages educational development based on instrumentation prototyping and research. Students with different backgrounds work together to develop prototype instruments based on new analytical technology. Derived instruments are provided to outside end-users for testing and development of applications. The resulting integration of education with research illustrates the transition of learning to real problem solving and provides a test of a new model for training young instrumentalists for analytical instrumentation research. Mechanisms of building a self-sustainable training program will be explored.