CAREER: Metallonitrene/Alkyne Metathesis and Beyond: Transition Metal Catalyzed Oxidative Amination For Organic Synthesis

本项目致力于发现催化C-N、C-C和C-O键形成的新化学方法，并将这些新方法应用于合成化学和医药相关的靶标。作为这项研究的一个组成部分，我们的目标是深入了解活性金属腈的形成条件，并了解不同的过渡金属及其配体环境如何影响硝烯配体的反应活性。对成功实施这一研究计划所产生的切实的科学和技术成果的补充是对人类潜力的隐性开发和对我们下一代科学领袖的教育。尽管该计划的一个重要教育部分涉及在培养创造力和严谨性的环境中对研究生进行高级科学培训，但该项目也将包括P.I.在本科生水平上开发和实施新课程和教学法的努力，重点是科学方法和问题解决，作为理解基础有机化学的一种手段。通过这个奖项，有机和高分子化学计划支持埃默里大学化学系西蒙·布莱基教授的研究。布莱基教授的研究工作围绕着开发新的级联反应，以在碳、氮和氧之间形成选定的化学键，从简单的构建块构建复杂的分子结构。这些反应预计将是变革性的，有可能影响新药的发现，简化重要含氮化合物的大规模合成过程，并获得在材料化学中应用的新功能基序。

This project is directed toward the discovery of new chemistry for catalytic C-N, C-C and C-O bond formation using high oxidation state transition metals with reactive nitrenoid or amide ligands and the application of these new methods to the synthesis of chemically and medicinally relevant targets. As an integral part of this research we aim to establish an in depth understanding of the requirements for the formation of reactive metallonitrenes and understand how different transition metals and their ligand environments affect the reactivity of the nitrene ligands. Complementing the tangible scientific and technological gains arising from the successful implementation of this research program is the implicit development of human potential and education of our next generation of scientific leaders. Although a prominent educational component of this program involves the advanced scientific training of graduate students in an environment that fosters creativity and rigor, this project will also encompass efforts by the P.I. to develop and implement new curriculum and pedagogy at the undergraduate level, with a focus on scientific method and problem solving as a means of understanding fundamental organic chemistry.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Simon Blakey of the Department of Chemistry at Emory University. Professor Blakey's research efforts revolve around the development of new cascade reactions for the formation of selected chemical bonds between carbon, nitrogen and oxygen, building complex molecular architecture from simple building blocks. These reactions are expected to be transformative, with the potential to impact the discovery of new medicines, streamline processes for the large scale synthesis of important nitrogen containing compounds and access new functional motifs for applications in materials chemistry.