CAREER: Metallonitrene/Alkyne Metathesis and Beyond: Transition Metal Catalyzed Oxidative Amination For Organic Synthesis

该项目旨在利用高氧化态过渡金属与反应性类氮或酰胺配体发现催化C-N， C-C和C-O键形成的新化学物质，并将这些新方法应用于化学和医学相关目标的合成。作为本研究的一个组成部分，我们旨在深入了解反应性金属腈的形成条件，并了解不同过渡金属及其配体环境如何影响亚硝基配体的反应性。这项研究计划的成功实施带来了有形的科学和技术成果，与之相辅相成的是人类潜能的隐性开发和下一代科学领袖的教育。虽然该项目的一个重要教育组成部分包括在培养创造力和严谨的环境中对研究生进行先进的科学训练，但该项目也将包括P.I.在本科阶段开发和实施新课程和教学法的努力，重点放在科学方法和解决问题上，作为理解基本有机化学的一种手段。有了这个奖项，有机和大分子化学项目支持了埃默里大学化学系西蒙·布莱基教授的研究。Blakey教授的研究工作围绕着开发新的级联反应，以形成碳、氮和氧之间选定的化学键，从简单的构建块构建复杂的分子结构。预计这些反应将具有变革性，有可能影响新药的发现，简化重要含氮化合物的大规模合成过程，并获得用于材料化学应用的新功能基序。

This project is directed toward the discovery of new chemistry for catalytic C-N, C-C and C-O bond formation using high oxidation state transition metals with reactive nitrenoid or amide ligands and the application of these new methods to the synthesis of chemically and medicinally relevant targets. As an integral part of this research we aim to establish an in depth understanding of the requirements for the formation of reactive metallonitrenes and understand how different transition metals and their ligand environments affect the reactivity of the nitrene ligands. Complementing the tangible scientific and technological gains arising from the successful implementation of this research program is the implicit development of human potential and education of our next generation of scientific leaders. Although a prominent educational component of this program involves the advanced scientific training of graduate students in an environment that fosters creativity and rigor, this project will also encompass efforts by the P.I. to develop and implement new curriculum and pedagogy at the undergraduate level, with a focus on scientific method and problem solving as a means of understanding fundamental organic chemistry.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Simon Blakey of the Department of Chemistry at Emory University. Professor Blakey's research efforts revolve around the development of new cascade reactions for the formation of selected chemical bonds between carbon, nitrogen and oxygen, building complex molecular architecture from simple building blocks. These reactions are expected to be transformative, with the potential to impact the discovery of new medicines, streamline processes for the large scale synthesis of important nitrogen containing compounds and access new functional motifs for applications in materials chemistry.