Novel Alternative Approaches to Metallocarbene and Metallonitrene Intermediates and Their Application in Synthesis

金属碳烯和金属氮烯中间体的新替代方法及其在合成中的应用

• 批准号: 418602-2013
• 负责人: Murphy, Graham
• 金额: $ 2.33万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596432
• 关键词: Novel; Alternative; Approaches; Metallocarbene; Metallonitrene

This proposal presents preliminary results and future strategies for a research program based on new applications of hypervalent iodine reagents in synthesis. We will explore the scope of our recently discovered a-difunctionalization strategy, focusing on fluorination reactions. Given the prevalence of fluorine in molecules of medicinal and commercial interest, this strategy could prove appealing to a broad community. Using our a-difluorination protocol for radiotracer compound synthesis would be instantly appealing.

该提案提出了基于高价碘试剂在合成中的新应用的研究计划的初步结果和未来策略。我们将探索最近发现的α-双官能化策略的范围，重点关注氟化反应。鉴于氟在具有医学和商业价值的分子中的普遍存在，这一策略可能会吸引广泛的社区。使用我们的α-放射性示踪剂化合物合成方案将立即吸引人。