Exploring the Photobehavior of Organic Molecules in Restricted Spaces

探索受限空间中有机分子的光行为

• 批准号: 0848017
• 负责人: Vaidhyanathan Ramamurthy
• 金额: $ 72万
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848017&HistoricalAwards=false
• 关键词: Exploring; Photobehavior; Organic; Molecules; Restricted

With support from the Organic and Macromolecular Chemistry Program in the Chemistry Division at the National Science Foundation, Professor V. Ramamurthy of the University of Miami will focus on the supramolecular photochemistry of a special class of supermolecules namely guest@host complexes. In the context of excited state chemistry, of the various organic hosts thus far examined, the octa acid (OA), a synthetic cavitand host, which forms a capsular structure that shields the hydrophobic guest organic molecule from the aqueous exterior, shows considerable potential. To establish OA as a useful reaction medium, the PI proposes to carry out experiments that seek answers to questions on the following topics: (a) Features controlling the stoichiometry of guest-to-OA complexes in water, (b) The dynamics of the OA capsule, (c) Controlled opening of the capsule, (d) The intra-capsular dynamics of the guest molecules, (e) Possible communication (electron, energy, and spin transfer) between encapsulated guest and free molecules present in water, (f) Selective orientation and conformational pre-organization of the guest within the OA capsule, (g) Influence products distribution through controlling the free space within the capsule. Topics (a) to (g) relate to the understanding of OA as a reaction medium and associated dynamics of the guest@host complex while (h) and (i) deal directly with the PI's primary interest of controlling photoreactions in restricted spaces. The long-range scientific goal is to develop, on the basis of well-established rules of molecular organic photochemistry and supramolecular chemistry, a model to predict the photobehavior of organic molecules in restricted spaces. The research proposed by Professor Ramamurthy will help train graduate students on several aspects of modern organic chemistry, physical organic chemistry and photochemistry. In addition to providing excellent training for the students associated with the project, Professor Ramamurthy has long been involved in fostering international collaborations, disseminating scientific information through edited books and guest edited journal special issues (in addition to refereed publications), giving invited talks at national, international conferences and universities and organizing national and international scientific conferences. He also serves the scientific community as a Senior Editor of Langmuir, an ACS journal. The PI has used his expertise in photochemistry to collaborate on writing two textbooks, (1) Principles of Modern Photochemistry: An Introduction and (2) Modern Molecular Organic Photochemistry with N. J. Turro, and J. C. Scaiano. In addition, the PI is currently developing a course titled "Being a Scientist" that includes topics such as scientific temper, ethics in science, mentor-student relationship, choosing scientific problems, writing, submitting and reviewing journal articles and grant proposals, developing oral and written communication skills, quality and quantity in scientific research, influence of citation index and impact factor, and the role of a scientist in society.

在美国国家科学基金会化学部有机和大分子化学项目的支持下，迈阿密大学的V. Ramamurthy教授将专注于一类特殊的超分子，即客体@主体复合物的超分子光化学。在激发态化学的背景下，迄今为止检查的各种有机主机，八酸（OA），一种合成的cavitand主机，它形成了一个胶囊结构，屏蔽的疏水性客体有机分子从水性外部，显示出相当大的潜力。为了将OA确立为有用的反应介质，PI建议进行实验，以寻求以下主题问题的答案：（a）控制水中客体-OA复合物的化学计量的特征，（B）OA胶囊的动力学，（c）胶囊的受控打开，（d）客体分子的胶囊内动力学，（e）可能的通信（f）OA胶囊内客体的选择性取向和构象预组织，（g）通过控制胶囊内的自由空间来影响产物分布。主题（a）至（g）涉及对OA作为反应介质的理解以及客体@主体复合物的相关动力学，而（h）和（i）则直接涉及PI的主要兴趣，即控制受限空间中的光反应。长期的科学目标是，在分子有机光化学和超分子化学的公认规则的基础上，开发一个模型来预测有机分子在有限空间中的光行为。 Ramamurthy教授提出的研究将有助于培养现代有机化学，物理有机化学和光化学几个方面的研究生。除了为与该项目相关的学生提供出色的培训外，Ramamurthy教授长期以来一直参与促进国际合作，通过编辑书籍和客座编辑期刊特刊（除了参考出版物）传播科学信息，在国家，国际会议和大学举办邀请演讲，并组织国家和国际科学会议。他还担任ACS期刊Langmuir的高级编辑，为科学界服务。PI利用他在光化学方面的专业知识合作编写了两本教科书，（1）现代光化学原理：介绍和（2）现代分子有机光化学。Turro和J.C.斯卡伊诺此外，PI目前正在开发一门名为“成为一名科学家”的课程，其中包括科学脾气，科学道德，师生关系，选择科学问题，撰写，提交和审查期刊文章和拨款申请，发展口头和书面沟通技巧，科学研究的质量和数量，引文索引和影响因子的影响，以及科学家在社会中的角色