Fine Tuning Photochemical Reactions Through Confinement and Cation-Organic Interactions
通过限制和阳离子有机相互作用微调光化学反应
基本信息
- 批准号:0531802
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-01-10 至 2009-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The PI seeks to continue his work in the use of zeolites to help effect diastereoselective and enantioselective photochemical reactions. The PI proposes that the cations which are present in the zeolite cage, along with the photoreactive molecule and chiral auxiliary, are critical to the success or failure of the asymmetric photoreactions. Cations present, hydronium ion concentrations present, and chiral inductors or auxiliaries present will be systematically varied. The main goal of the project period is to use this information to develop a model to help one predict and plan enantioselective photoreactions within zeolites. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. V. Ramamurthy of the Department of Chemistry at Tulane University. Dr. Ramamurthy will work on using zeolites to facilitate asymmetric photochemical reactions. The photochemical reactions to be studied produce molecules which are chiral (have two nonsuperimposable mirror images) and make only one of the two possible forms (a single enantiomer). Development of this family of reactions is one of the most important problems facing the pharmaceutical industry today. When developed, Dr. Ramamurthy's work could be applied to the syntheses of a number of biologically active molecules. Students trained during the course of this work will gain skills needed by the pharmaceutical industry which now produces a number of single enantiomer compounds.
PI寻求继续他的工作,在使用沸石,以帮助影响非对映选择性和对映选择性的光化学反应。 PI提出沸石笼中的阳离子与光反应性分子和手性助剂一起沿着存在,对不对称光反应的成功或失败至关重要。 存在的阳离子、存在的水合氢离子浓度和存在的手性诱导剂或助剂将系统地变化。 项目期间的主要目标是利用这些信息开发一个模型,以帮助预测和规划沸石内的对映选择性光反应。 有了这个奖项,有机和高分子化学计划正在支持杜兰大学化学系的V. Ramamurthy博士的研究。 Ramamurthy博士将致力于使用沸石来促进不对称光化学反应。 待研究的光化学反应产生手性分子(具有两个不可重叠的镜像),并且仅产生两种可能形式中的一种(单一对映体)。 这类反应的发展是当今制药工业面临的最重要的问题之一。 当开发完成后,Ramamurthy博士的工作可以应用于许多生物活性分子的合成。 在这项工作的过程中培训的学生将获得制药行业所需的技能,现在生产一些单一的对映体化合物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vaidhyanathan Ramamurthy其他文献
Large molecular motions are tolerated in crystals of diamine double salt of trans-chlorocinnamic acids with trans-1,2-diaminocyclohexane.
反式-氯肉桂酸与反式-1,2-二氨基环己烷的二胺复盐晶体可耐受大分子运动。
- DOI:
10.1021/ol050330u - 发表时间:
2005 - 期刊:
- 影响因子:5.2
- 作者:
Arunkumar Natarajan;J. Mague;Kailasam Venkatesan;Vaidhyanathan Ramamurthy - 通讯作者:
Vaidhyanathan Ramamurthy
Regioselective photodimerization of pyridyl-butadienes within cucurbit[8]uril cavities.
葫芦[8]脲腔内吡啶基丁二烯的区域选择性光二聚化。
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:3.2
- 作者:
Murthy V S N Maddipatla;Mahesh Pattabiraman;Arunkumar Natarajan;Karan Srivastav;J. Mague;Vaidhyanathan Ramamurthy - 通讯作者:
Vaidhyanathan Ramamurthy
Alkali Ion Exchanged Nafion as a Confining Medium for Photochemical Reactions†
碱离子交换 Nafion 作为光化学反应的限制介质†
- DOI:
10.1562/2005-05-05-ra-515 - 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
S. Arumugam;Lakshmi S. Kaanumalle;Vaidhyanathan Ramamurthy - 通讯作者:
Vaidhyanathan Ramamurthy
Role of hydrogen bonds in molecular packing of photoreactive crystals: templating photodimerization of protonated stilbazoles in crystalline state with a combination of water molecules and chloride ions
氢键在光反应晶体分子堆积中的作用:结晶态质子化芪唑与水分子和氯离子的组合的模板光二聚化
- DOI:
10.1039/c4pp00221k - 发表时间:
2014 - 期刊:
- 影响因子:3.1
- 作者:
B. Mondal;Tingting Zhang;Rajeev Prabhakar;B. Captain;Vaidhyanathan Ramamurthy - 通讯作者:
Vaidhyanathan Ramamurthy
Cation-pi interactions as a tool to enhance the power of a chiral auxiliary during asymmetric photoreactions within zeolites.
阳离子-π相互作用作为增强沸石内不对称光反应期间手性助剂能力的工具。
- DOI:
10.1039/b209810e - 发表时间:
2003 - 期刊:
- 影响因子:4.9
- 作者:
Lakshmi S. Kaanumalle;J. Sivaguru;N. Arunkumar;S. Karthikeyan;Vaidhyanathan Ramamurthy - 通讯作者:
Vaidhyanathan Ramamurthy
Vaidhyanathan Ramamurthy的其他文献
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{{ truncateString('Vaidhyanathan Ramamurthy', 18)}}的其他基金
CAS: Photochemistry of spatially confined organic molecules
CAS:空间受限有机分子的光化学
- 批准号:
2204046 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Continuing Grant
Medium Matters: Merging Photochemistry with Supramolecular-, Nano-, and Green Chemistries
介质问题:将光化学与超分子、纳米和绿色化学相结合
- 批准号:
1807729 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Standard Grant
Supramolecular-Surface Photochemistry: Exploring the Excited state Behavior of Confined Molecules Organized on Surfaces
超分子表面光化学:探索表面组织的限域分子的激发态行为
- 批准号:
1411458 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Continuing Grant
CRIF:MU Acquisition of a Benchtop Electrospray Ionization Time of Flight Mass Spectrometer
CRIF:MU 购置台式电喷雾电离飞行时间质谱仪
- 批准号:
0946858 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Standard Grant
Exploring the Photobehavior of Organic Molecules in Restricted Spaces
探索受限空间中有机分子的光行为
- 批准号:
0848017 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Continuing Grant
Fine Tuning Photochemical Reactions Through Confinement and Cation-Organic Interactions
通过限制和阳离子有机相互作用微调光化学反应
- 批准号:
0212042 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Continuing Grant
U.S.-Japan Joint Seminar: Supramolecular Photochemistry
美日联合研讨会:超分子光化学
- 批准号:
9900387 - 财政年份:1999
- 资助金额:
-- - 项目类别:
Standard Grant
Stereochemical Control of Photo-reactions within Zeolites
沸石内光反应的立体化学控制
- 批准号:
9904187 - 财政年份:1999
- 资助金额:
-- - 项目类别:
Continuing Grant
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