New Methods for the Synthesis of Peroxides

过氧化物合成新方法

• 批准号: 0848121
• 负责人: Scott Rychnovsky
• 金额: $ 42万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848121&HistoricalAwards=false
• 关键词: New; Methods; Synthesis; Peroxides

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will focus on the development of new methods for the synthesis of organic peroxides. The peroxide moiety, characterized by the presence of an oxygen-oxygen bond, is found in many biologically active natural products. Preliminary data suggests that the core structures of several families of natural products can be constructed by new chemical reactions. These processes will be developed, and their application to more complicated structures will be pursued. Mechanistic studies will be conducted to provide insight into how these transformations proceed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Keith A. Woerpel of the Department of Chemistry at the University of California, Irvine. Professor Woerpel's research focuses on the development of new chemical reactions for the synthesis of complex organic molecules. Peroxides show considerable promise as drug candidates, but they are difficult to synthesize because of their inherent instability. Successful development of methods for the synthesis of peroxides would lead to the development of new drugs for the treatment of malaria and cancer.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。该项目将侧重于开发合成有机过氧化物的新方法。 过氧化物部分，其特征在于存在氧-氧键，存在于许多生物活性天然产物中。 初步数据表明，几个天然产物家族的核心结构可以通过新的化学反应来构建。 这些工艺将得到发展，并将继续应用于更复杂的结构。 有机及高分子化学系获此殊荣，以支持基思A教授的研究。加州大学欧文分校化学系的Woerpel说。 Woerpel教授的研究重点是开发用于合成复杂有机分子的新化学反应。 过氧化物作为候选药物显示出相当大的前景，但由于其固有的不稳定性，它们难以合成。 过氧化物合成方法的成功开发将导致治疗疟疾和癌症的新药的开发。