Collaborative Research: Molecular basis of life history evolution in Drosophila
合作研究:果蝇生命史进化的分子基础
基本信息
- 批准号:0848337
- 负责人:
- 金额:$ 50.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-03-01 至 2015-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Humans and other organisms are enormously genetically variable, even for traits like lifespan and fertility. During the past decade, genes affecting longevity and fertility have been discovered by mutating those genes in laboratory animals and observing the resulting effects. For example, mutations in genes controlling insulin signaling can increase the longevity of worms, flies, and mice by 100% or more. These results beg the question of whether the same genes are responsible for natural variation among individuals, populations, and species in longevity and fertility. This project addresses this question by discovering the genetic basis of life history differences in artificially-selected and in natural populations of an insect, Drosophila melanogaster, for which powerful genetic techniques are available. Expression profiling, genetic mapping, and new statistical techniques will be deployed to identify the genes contributing to longevity and fertility differences between populations. Genes causing variation in longevity and fertility have significant impact on human health and well being. Most of the proposed candidate genes are shared between insects and mammals (including humans), and knowing which genes cause variation in non-inbred animals has important implications for biomedicine. Other significant effects will include training of undergraduate and graduate researchers in the laboratories of all three investigators, and at two ?mini-symposia? that will include all participants, and development of new analytical tools.
人类和其他生物体的遗传变异性很大,即使是寿命和生育能力等特征也是如此。在过去的十年中,通过在实验室动物中突变这些基因并观察所产生的影响,发现了影响寿命和生育力的基因。 例如,控制胰岛素信号的基因突变可以使蠕虫、苍蝇和小鼠的寿命增加100%或更多。 这些结果引出了一个问题,即是否相同的基因负责个体、种群和物种之间在寿命和生育力方面的自然变异。 该项目通过发现一种昆虫-黑腹果蝇(Drosophila melanogaster)-的人工选择种群和自然种群中生活史差异的遗传基础来解决这一问题。将部署表达谱分析、遗传图谱和新的统计技术,以确定有助于人口之间长寿和生育差异的基因。导致寿命和生育力变异的基因对人类健康和福祉有重大影响。 大多数候选基因都是昆虫和哺乳动物(包括人类)共有的,知道哪些基因会导致非近亲繁殖动物的变异对生物医学具有重要意义。 其他重大影响将包括培训的本科生和研究生研究人员在实验室的所有三个调查员,并在两个?小型研讨会这将包括所有参与者,并开发新的分析工具。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kimberly Hughes其他文献
Virtual Service-Learning Using Facebook Live
使用 Facebook Live 进行虚拟服务学习
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:2.6
- 作者:
Kimberly Hughes;Emily Carder - 通讯作者:
Emily Carder
Kimberly Hughes的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kimberly Hughes', 18)}}的其他基金
Intergovernmental Mobility Award
政府间流动奖
- 批准号:
2240985 - 财政年份:2022
- 资助金额:
$ 50.51万 - 项目类别:
Intergovernmental Personnel Award
UTeach and NYC: A Design Research Partnership to Expand and Improve High School Computer Science Education for Underrepresented Urban Youth
UTeach 和纽约市:设计研究合作伙伴关系,旨在扩大和改善代表性不足的城市青年的高中计算机科学教育
- 批准号:
1837687 - 财政年份:2018
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: Evolutionary lability and adaptive plasticity in physiological and molecular mechanisms of behavior
合作研究:行为的生理和分子机制中的进化不稳定性和适应性可塑性
- 批准号:
1354775 - 财政年份:2014
- 资助金额:
$ 50.51万 - 项目类别:
Continuing Grant
Social interactions and the maintenance of genetic polymorphism
社会互动与遗传多态性的维持
- 批准号:
1257735 - 财政年份:2013
- 资助金额:
$ 50.51万 - 项目类别:
Continuing Grant
Collaborative Research: Behavioral and Genetic Mechanisms for Frequency-Dependent Survival and Mating Advantage in Guppies
合作研究:孔雀鱼频率依赖性生存和交配优势的行为和遗传机制
- 批准号:
0934451 - 财政年份:2009
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: Behavioral and Genetic Mechanisms for Frequency-Dependent Survival and Mating Advantage in Guppies
合作研究:孔雀鱼频率依赖性生存和交配优势的行为和遗传机制
- 批准号:
0744880 - 财政年份:2008
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Natural Genetic Variation and Gene Expression in Male Courtship Behavior of Drosophila Melanogaster
论文研究:果蝇雄性求爱行为的自然遗传变异和基因表达
- 批准号:
0608375 - 财政年份:2006
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: The Role of Frequency Dependent Selection in the Evolution of Color Pattern Polymorphism in Guppies
合作研究:频率依赖选择在孔雀鱼颜色图案多态性进化中的作用
- 批准号:
0128820 - 财政年份:2002
- 资助金额:
$ 50.51万 - 项目类别:
Continuing Grant
CAREER/RUI: Genetic Basis of Sperm Precedence and Sex-Specific Fitness in Fruit Flies
职业/RUI:果蝇精子优先和性别特异性适应性的遗传基础
- 批准号:
0296177 - 财政年份:2000
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
CAREER/RUI: Genetic Basis of Sperm Precedence and Sex-Specific Fitness in Fruit Flies
职业/RUI:果蝇精子优先和性别特异性适应性的遗传基础
- 批准号:
9734008 - 财政年份:1998
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
Collaborative Research: Deciphering the mechanisms of marine nitrous oxide cycling using stable isotopes, molecular markers and in situ rates
合作研究:利用稳定同位素、分子标记和原位速率破译海洋一氧化二氮循环机制
- 批准号:
2319097 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: CyberTraining: Implementation: Medium: Transforming the Molecular Science Research Workforce through Integration of Programming in University Curricula
协作研究:网络培训:实施:中:通过将编程融入大学课程来改变分子科学研究人员队伍
- 批准号:
2321045 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: CyberTraining: Implementation: Medium: Transforming the Molecular Science Research Workforce through Integration of Programming in University Curricula
协作研究:网络培训:实施:中:通过将编程融入大学课程来改变分子科学研究人员队伍
- 批准号:
2321044 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
CAS: Collaborative Research: Ambient Polyvinyl Chloride (PVC) Upgrading Using Earth-Abundant Molecular Electrocatalysts
CAS:合作研究:使用地球上丰富的分子电催化剂升级常温聚氯乙烯 (PVC)
- 批准号:
2347912 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
CAS: Collaborative Research: Ambient Polyvinyl Chloride (PVC) Upgrading Using Earth-Abundant Molecular Electrocatalysts
CAS:合作研究:使用地球上丰富的分子电催化剂升级常温聚氯乙烯 (PVC)
- 批准号:
2347913 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: Catholyte Molecular Design For Non-aqueous Mg-organic Hybrid Redox Flow Batteries
合作研究:非水镁有机混合氧化还原液流电池的阴极电解液分子设计
- 批准号:
2419938 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: Deciphering the mechanisms of marine nitrous oxide cycling using stable isotopes, molecular markers and in situ rates
合作研究:利用稳定同位素、分子标记和原位速率破译海洋一氧化二氮循环机制
- 批准号:
2319096 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: Deciphering the mechanisms of marine nitrous oxide cycling using stable isotopes, molecular markers and in situ rates
合作研究:利用稳定同位素、分子标记和原位速率破译海洋一氧化二氮循环机制
- 批准号:
2319098 - 财政年份:2024
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: DMREF: Predicting Molecular Interactions to Stabilize Viral Therapies
合作研究:DMREF:预测分子相互作用以稳定病毒疗法
- 批准号:
2325392 - 财政年份:2023
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Uncovering eusocial pathways and consequences: Phylogenomics, morphological, and molecular evolution in Synalpheus snapping shrimps.
合作研究:RUI:揭示真社会途径和后果:鳄虾的系统基因组学、形态学和分子进化。
- 批准号:
2345470 - 财政年份:2023
- 资助金额:
$ 50.51万 - 项目类别:
Standard Grant