Development of a new photolabile protecting group toolbox

新型光不稳定保护基团工具箱的开发

• 批准号: 0848489
• 负责人: Pengfei Wang
• 金额: $ 37.5万
• 依托单位: University of Alabama at Birmingham
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848489&HistoricalAwards=false
• 关键词: Development; new; photolabile; protecting; group

This project focuses on the development of novel photolabile protecting groups (PPGs). PPGs are indispensable tools in both basic and applied sciences. However, simple and practically useful PPGs for some important functional groups are not yet available. The goal of this project is to enrich the PPG toolbox with a series of structurally simple and mechanistically novel PPGs for carbonyl, hydroxyl, and amino groups, and to explore their synthetic applications. Highly efficient green chemistry methods for PPG installation will also be pursued, along with mechanistic studies of relevant and interesting reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Pengfei Wang of the Department of Chemistry at the University of Alabama at Birmingham. Professor Wang's research efforts are focused on the development of novel photolabile protecting groups and their applications. Successful development of the new methodologies will have a positive impact on organic synthesis, drug delivery, photolithography, and biochemistry.

该项目的重点是开发新型的光不稳定保护基团（PPG）。 PPG是基础科学和应用科学中不可或缺的工具。 然而，针对一些重要功能组的简单且实用的PPG尚未可用。 该项目的目标是用一系列结构简单和机械新颖的羰基，羟基和氨基的PPG来丰富PPG工具箱，并探索它们的合成应用。 PPG装置的高效绿色化学方法也将被追求，沿着相关和有趣的反应的机理研究。有了这个奖项，有机和高分子化学计划支持伯明翰亚拉巴马大学化学系的王鹏飞教授的研究。 王教授的研究工作主要集中在新型光不稳定保护基团的开发及其应用。 新方法学的成功开发将对有机合成、药物输送、光刻和生物化学产生积极影响。