Development of clean, fast, and mild photochemical reactions to break C-N, C-O, and C-S bonds

在这项由化学系化学结构、动力学和机理B(CSDM-B)计划资助的项目中，阿拉巴马大学伯明翰分校的王鹏飞教授正在研究新的光化学反应，以开发光可移除保护基团(PPG)，在化学、生物化学、生物物理、医学和材料科学中具有潜在的应用前景。PPG是在广泛的基础和应用研究领域中使用的不可或缺的工具，特别是当需要在中性和无试剂的条件下，通过精确的空间和时间控制来去除保护基团时。这项工作的更广泛的影响包括发现新的PPG可能带来的社会效益，以及在学术环境中为学生(包括来自代表不足的群体的学生)发展一个训练基地。然而，通过光化学在快速的初级光化学过程中打破C-N键直接释放氨基的情况很少见。本项目致力于开发新的光化学反应及其在开发结构简单和机械上新颖的氮(胺)、硫(硫醇)和其他原子的耐光保护基团方面的应用。人们正在研究和优化具有不同化学/光化学性质的新型PPG，这些性质主要基于三苯基衍生物的光解。

In this project funded by the Chemical Structure, Dynamics, and Mechanisms-B (CSDM-B) Program of the Chemistry Division, Professor Pengfei Wang of the University of Alabama at Birmingham is studying new photochemical reactions to develop photoremovable protecting groups (PPGs) for potential applications in chemistry, biochemistry, biophysics, medicine, and materials science. PPGs are indispensable tools that are used in a broad range of basic and applied research areas, especially when removal of protecting groups under neutral and reagent-free conditions with precise spatial and temporal control is desired. The broader impacts of this work include potential societal benefits from the discovery of new PPGs as well as the development of a training ground for students (including students from underrepresented groups) in an academic setting.The photochemical release of an amino group is of great importance in many research areas. However, direct release of an amino group by photochemically breaking the C-N bond in a fast, primary photochemical process is rare. This project focuses on the development of new photochemical reactions and their applications in the development of structurally simple and mechanistically novel photolabile protecting groups for nitrogen (amines), sulfur (thiols) and other atoms. New PPGs with different chemical/photochemical properties, largely based upon photosolvolysis of trityl derivatives, are being examined and optimized.