Development of clean, fast, and mild photochemical reactions to break C-N, C-O, and C-S bonds

该项目由化学学部化学结构、动力学和机理b （CSDM-B）项目资助，阿拉巴马大学伯明翰分校的王鹏飞教授正在研究新的光化学反应，以开发可光移保护基团（PPGs），在化学、生物化学、生物物理学、医学和材料科学等领域具有潜在的应用前景。ppg是广泛用于基础和应用研究领域的不可缺少的工具，特别是当需要在中性和无试剂条件下去除保护基团时，需要精确的空间和时间控制。这项工作的更广泛影响包括发现新的ppg所带来的潜在社会效益，以及为学生（包括来自代表性不足群体的学生）在学术环境中的培训场地的发展。氨基的光化学释放在许多研究领域具有重要意义。然而，在快速的初级光化学过程中，通过光化学破坏C-N键来直接释放氨基是很少见的。本项目的重点是开发新的光化学反应及其在开发结构简单和机械新颖的氮（胺）、硫（硫醇）和其他原子的光稳定性保护基团方面的应用。新的PPGs具有不同的化学/光化学性质，主要是基于三烷基衍生物的光溶解，正在研究和优化。

In this project funded by the Chemical Structure, Dynamics, and Mechanisms-B (CSDM-B) Program of the Chemistry Division, Professor Pengfei Wang of the University of Alabama at Birmingham is studying new photochemical reactions to develop photoremovable protecting groups (PPGs) for potential applications in chemistry, biochemistry, biophysics, medicine, and materials science. PPGs are indispensable tools that are used in a broad range of basic and applied research areas, especially when removal of protecting groups under neutral and reagent-free conditions with precise spatial and temporal control is desired. The broader impacts of this work include potential societal benefits from the discovery of new PPGs as well as the development of a training ground for students (including students from underrepresented groups) in an academic setting.The photochemical release of an amino group is of great importance in many research areas. However, direct release of an amino group by photochemically breaking the C-N bond in a fast, primary photochemical process is rare. This project focuses on the development of new photochemical reactions and their applications in the development of structurally simple and mechanistically novel photolabile protecting groups for nitrogen (amines), sulfur (thiols) and other atoms. New PPGs with different chemical/photochemical properties, largely based upon photosolvolysis of trityl derivatives, are being examined and optimized.