Stochastic methods in chemistry and biophysics

化学和生物物理学中的随机方法

• 批准号: 0848809
• 负责人: Frank Brown
• 金额: $ 43.5万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848809&HistoricalAwards=false
• 关键词: Stochastic; methods; chemistry; biophysics

Frank Brown of the University of California, Santa Barbara is supported by an award from the Theoretical and Computational Chemistry program within the Division of Chemistry for the development of theoretical tools to 1) model lipid bilayers and biomembranes for use in simulating complex biochemical and biophysical phenomena and 2) to model single-molecule spectroscopy experiments with emphasis on photon counting measurements that provide both time and frequency domain resolution. Dr. Brown's Fourier-Space Brownian Dynamics (FSBD) algorithm allows hydrodynamically consistent modeling of inhomogeneous membrane surfaces over micron length scales at time scales of seconds or longer.The research is having a broad impact on the interpretation of experiments that enhance our understanding of biological phenomena such as the diffusion of membrane proteins in crowded cellular environments or the structure and dynamics of human red blood cells. Dr. Brown communicates the excitement and importance of science to grade school children through his participation in the Physics Circus and Chemistry Outreach programs at UCSB.This project is supported by the Theoretical and Computational Chemistry Program in a co-funding arrangement with Molecular Biophysics of Molecular and Cellular Biology.

加州大学圣巴巴拉分校的Frank Brown获得了化学系理论与计算化学项目的奖励，因为他开发了理论工具，1)模拟脂质双层和生物膜，用于模拟复杂的生化和生物物理现象，2)模拟单分子光谱实验，重点是提供时域和频域分辨率的光子计数测量。布朗博士的傅里叶-空间布朗动力学（FSBD）算法允许在秒或更长的时间尺度上对微米尺度上的非均匀膜表面进行流体动力学一致性建模。这项研究正在对实验的解释产生广泛的影响，这些实验增强了我们对生物现象的理解，例如在拥挤的细胞环境中膜蛋白的扩散或人类红细胞的结构和动力学。布朗博士通过参加UCSB的物理马戏团和化学推广项目，向小学生传达科学的兴奋和重要性。该项目由理论和计算化学项目与分子和细胞生物学的分子生物物理学共同资助。