SBIR Phase II: Themally-Actuated Microfluidic Systems

SBIR 第二阶段：热驱动微流体系统

• 批准号: 0848967
• 负责人: Richard Welle
• 金额: $ 50万
• 依托单位: Phasiks Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848967&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Themally; Actuated

This Small Business Innovation Research (SBIR) Phase II project will develop a new technology to satisfy the need for reliable and inexpensive ultifunctional fluid handling and control in microfluidic devices. Building on the Phase I results, which demonstrated the fundamental concepts of thermal actuation of microfluidics, the goals of the Phase II program are to demonstrate, develop, and optimize thermal actuation techniques for all useful microfluidic fluid handling functions, and to demonstrate the ability to combine the various functions into an integrated device. To achieve these goals, methods will be developed for fabricating, operating, evaluating, and optimizing devices demonstrating each function of interest in a realistic application setting. The end result will be a complete microfluidic tool box that can be applied to supply fluid handling and control functions to a variety of customers for implementation in commercial microfluidic devices. The broader impacts of this research are in the areas of biomedical and biopharmaceutical research, and clinical diagnostics. Successful completion of this Phase II program would result in development of a set of thermally-actuated functional elements enabling a less complex and more cost-effective biomedical microfluidic device; the "lab-on-a-chip" system. The potential commercial value is significant. The increasing complexity of molecular diagnostic tests and the pressure to provide cost-effective, reliable, and repeatable point-of-care assays will continue to increase the demand for such systems. Societal impact of such a technology will include substantial cost reduction, more accurate and consistent results, and improved health care resulting from more rapid and specific treatment.

这个小型企业创新研究（SBIR）第二阶段项目将开发一种新技术，以满足微流体设备中可靠和廉价的多功能流体处理和控制的需求。第一阶段的结果，证明了微流体的热致动的基本概念的基础上，第二阶段计划的目标是证明，开发和优化所有有用的微流体流体处理功能的热致动技术，并证明有能力将各种功能联合收割机组合成一个集成的设备。为了实现这些目标，将开发用于制造，操作，评估和优化设备的方法，这些设备在现实的应用环境中展示了每个感兴趣的功能。最终的结果将是一个完整的微流体工具箱，可用于为各种客户提供流体处理和控制功能，以在商业微流体设备中实施。这项研究的更广泛的影响是在生物医学和生物制药研究领域，以及临床诊断。该第二阶段计划的成功完成将导致开发一套热致动功能元件，从而实现更简单且更具成本效益的生物医学微流体设备;“芯片实验室”系统。潜在的商业价值是巨大的。分子诊断测试的日益复杂性以及提供具有成本效益、可靠和可重复的即时检测的压力将继续增加对此类系统的需求。这种技术的社会影响将包括大幅降低成本，更准确和一致的结果，以及通过更快速和更具体的治疗改善医疗保健。