Synthesis of Heterocycles via New Metal-Catalyzed Transformations

通过新金属催化转化合成杂环

• 批准号: 0848982
• 负责人: Valery Fokin
• 金额: $ 42.5万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848982&HistoricalAwards=false
• 关键词: Synthesis; Heterocycles; via; New; Metal

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The goal of this project is to develop practical catalysts for the selective synthesis of heterocyclic molecules by transition metal-catalyzed activation of alkynes. The emphasis is placed on the synthesis of the five-membered azole heterocycles. The studies will involve design of the catalysts, investigation of their activity, and examination of the mechanism of the reactions, representing all aspects of reaction discovery and practical process development. Heat flow calorimetry, parallel synthesis and reaction monitoring, and design of experiments algorithms will be used to study and optimize the initial discoveries of novel reactivity.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Valery V. Fokin of the Department of Chemistry at The Scripps Research Institute. Professor Fokin's research program revolves around the development of practical catalytic methods for the synthesis of heterocyclic molecules from readily available alkynes via formation of C-N bonds. Successful development of the methodology will have an impact on synthesis in the pharmaceutical, materials, and agricultural industries.

该奖项根据 2009 年美国复苏和再投资法案（公法 111-5）提供资金。该项目的目标是开发实用的催化剂，通过过渡金属催化活化炔烃来选择性合成杂环分子。重点是五元唑杂环的合成。这些研究将涉及催化剂的设计、其活性的研究以及反应机理的检查，代表了反应发现和实际工艺开发的各个方面。热流量热法、平行合成和反应监测以及实验算法设计将用于研究和优化新型反应性的初步发现。有机和高分子化学项目通过该奖项支持斯克里普斯研究所化学系 Valery V. Fokin 教授的研究。 Fokin 教授的研究项目围绕开发实用的催化方法，通过形成 C-N 键从容易获得的炔烃合成杂环分子。 该方法的成功开发将对制药、材料和农业行业的合成产生影响。