New Approaches to Catalytic Activation of Alkynes

炔烃催化活化的新方法

• 批准号: 1302043
• 负责人: Valery Fokin
• 金额: $ 43.5万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1302043&HistoricalAwards=false
• 关键词: New; Approaches; Catalytic; Activation; Alkynes

In this project funded by the Chemical Synthesis Program of the Chemistry Division of the National Science Foundation, Professor Valery V. Fokin of the Department of Chemistry at The Scripps Research Institute will develop a mechanistically driven approach to catalytic reaction optimization that takes advantage of real-time monitoring of reactions without putting them into constraints of model systems. Reactions to be probed involve 2+3 cycloadditions to alkynes to form a variety of five-membered heterocycles which undergo further reactions to form a number of reactive intermediates, including metal carbene complexes. This research focuses on the critical role of transient catalyst behaviors and, in the context of the proposed work, on the defining role of weak, rapid, and reversible interactions of alkynes with transition metal catalysts.A successful outcome to this research will result in practical synthetic methods that will allow chemists, biologists, and materials scientists to reliably assemble a variety of complex molecules with defined geometry from readily available starting materials under experimentally simple conditions. Practical synthesis of such molecules will have an impact on new and inexpensive pharmaceuticals, new materials, and advanced agrochemicals. Additionally, the next generation of scientists in catalytic synthetic chemistry will be trained in state-of-the-art techniques.

在这个由国家科学基金会化学部化学合成计划资助的项目中，斯克里普斯研究所化学系的Valery V.Fokin教授将开发一种机械驱动的催化反应优化方法，该方法利用对反应的实时监控，而不会将它们置于模型系统的约束之下。待探索的反应涉及2+3环加成到炔烃上以形成各种五元杂环，这些杂环经过进一步的反应形成许多活性中间体，包括金属卡宾配合物。这项研究的重点是瞬时催化剂行为的关键作用，以及在拟议的工作背景下，炔烃与过渡金属催化剂的弱、快速和可逆相互作用的定义作用。这项研究的成功结果将导致实用的合成方法，使化学家、生物学家和材料科学家能够在简单的实验条件下从容易获得的起始材料中可靠地组装各种具有特定几何结构的复杂分子。这些分子的实际合成将对新的和廉价的药品、新材料和先进的农用化学品产生影响。此外，催化合成化学的下一代科学家将接受最先进技术的培训。