New Approaches to Catalytic Activation of Alkynes

炔烃催化活化的新方法

• 批准号: 1660373
• 负责人: Valery Fokin
• 金额: $ 24.51万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1660373&HistoricalAwards=false
• 关键词: New; Approaches; Catalytic; Activation; Alkynes

In this project funded by the Chemical Synthesis Program of the Chemistry Division of the National Science Foundation, Professor Valery V. Fokin of the Department of Chemistry at The Scripps Research Institute will develop a mechanistically driven approach to catalytic reaction optimization that takes advantage of real-time monitoring of reactions without putting them into constraints of model systems. Reactions to be probed involve 2+3 cycloadditions to alkynes to form a variety of five-membered heterocycles which undergo further reactions to form a number of reactive intermediates, including metal carbene complexes. This research focuses on the critical role of transient catalyst behaviors and, in the context of the proposed work, on the defining role of weak, rapid, and reversible interactions of alkynes with transition metal catalysts.A successful outcome to this research will result in practical synthetic methods that will allow chemists, biologists, and materials scientists to reliably assemble a variety of complex molecules with defined geometry from readily available starting materials under experimentally simple conditions. Practical synthesis of such molecules will have an impact on new and inexpensive pharmaceuticals, new materials, and advanced agrochemicals. Additionally, the next generation of scientists in catalytic synthetic chemistry will be trained in state-of-the-art techniques.

在这个由美国国家科学基金会化学部化学合成计划资助的项目中，斯克里普斯研究所化学系的Valery V. Fokin教授将开发一种机械驱动的催化反应优化方法，该方法利用实时监测反应，而不将其置于模型系统的约束中。待探测的反应涉及与炔的2+3环加成以形成各种五元杂环，其经历进一步反应以形成许多反应性中间体，包括金属卡宾络合物。 本研究的重点是瞬态催化剂行为的关键作用，并在拟议的工作的背景下，对过渡金属催化剂的炔烃的弱，快速和可逆的相互作用的定义作用。和材料科学家在实验简单的条件下，从现成的起始材料可靠地组装各种具有确定几何形状的复杂分子。 这些分子的实际合成将对新的廉价药物、新材料和先进的农用化学品产生影响。此外，催化合成化学的下一代科学家将接受最先进技术的培训。