Annotating unknown microbial gene functions with organic matter change

用有机物变化注释未知微生物基因功能

• 批准号: DE160100248
• 负责人: Dr Benjamin Woodcroft
• 金额: $ 26.08万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-06-22 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE160100248
• 关键词: Annotating; unknown; microbial; gene; functions

This project intends to develop a new method for determining the function of microbial genomes. Microbes are all pervasive on Earth. It is now possible to routinely sequence microbial genomes. However, the function of most genes encoded on these genomes remains elusive, severely limiting our understanding of most ecosystems. This project seeks to develop new methods to assign function to uncharacterised genes, by correlating changes in metabolite abundance with gene expression in a model permafrost thaw peatland. Determining the function of uncharacterised genes has widespread implications for microbial ecology and its numerous real-world applications, from determining soil greenhouse gas emissions to understanding human intestinal flora.

该项目旨在开发一种确定微生物基因组功能的新方法。微生物在地球上无处不在。现在有可能对微生物基因组进行常规测序。然而，这些基因组上编码的大多数基因的功能仍然难以捉摸，严重限制了我们对大多数生态系统的理解。该项目旨在开发新的方法来分配功能的未表征的基因，通过相关的代谢产物丰度的变化与基因表达在一个模型永久冻土融化泥炭地。确定未表征基因的功能对微生物生态学及其众多现实应用具有广泛的影响，从确定土壤温室气体排放到了解人类肠道植物群。