Integrative Modeling/Simulation and Experimental Validation of Therapeutic Nanodiamond Materials

治疗性纳米金刚石材料的综合建模/模拟和实验验证

• 批准号: 0856492
• 负责人: Dean Ho
• 金额: $ 113.12万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0856492&HistoricalAwards=false
• 关键词: Integrative; Modeling; Simulation; Experimental; Validation

Nanodiamonds possess several properties that enable their versatile application towards drug delivery. For example, they can carry and release proteins, small molecules, genetic material, etc. They can also be applied as particle-based vehicles for pervasive delivery, or integrated within devices for localized treatment. To optimize the therapeutic potential of the nanodiamonds, a broader understanding of their chemical/mechanical properties will be addressed by this research program. This information will uncover the fundamental science underlying nanodiamond particle structure, chemical composition/distribution on nanodiamond surfaces, and drug attachment/detachment mechanisms, etc. This program unites complementary expertise in mechanical/biomedical engineering, chemistry, and engineering education research towards the comprehensive analysis of fundamental nanodiamond properties via atomistic, quantum, and continuum modeling/simulations. Information gleaned from these studies will be integrated with experimental validation towards the intelligent design of therapeutic nanodiamond particles and devices.This program will merge nanodiamond and engineering education research to train the next generation of scientific/engineering leaders. The educational/outreach plan will integrate educational module design, faculty guest lectures, and custom designed experimental kits to impact a diverse student population and increase nanotechnology interest. These modules will also be co-designed with partner teachers. Module topics will include an introduction to nanocarbon materials/devices, nanobiology, etc. Images derived from the modeling/simulation project objectives will be used to accomplish the challenge of visually illustrating nanotechnology concepts. Module/experimental kit implementation will be coordinated by postdoctoral researchers and graduate students, and feedback/analysis of the outreach program efficacy will be conducted in collaboration with the Northwestern Center for Engineering Education Research.

纳米钻石具有几种特性，使其能够在药物输送方面得到广泛应用。例如，它们可以携带和释放蛋白质、小分子、遗传物质等。它们还可以作为基于颗粒的载体广泛应用，或集成到设备中进行局部治疗。为了优化纳米钻石的治疗潜力，这项研究计划将更广泛地了解它们的化学/机械性能。这些信息将揭示纳米钻石颗粒结构、纳米钻石表面的化学成分/分布以及药物附着/分离机制等基础科学。该项目将机械/生物医学工程、化学和工程教育研究方面的互补专业知识结合在一起，通过原子、量子和连续介质建模/模拟来综合分析纳米钻石的基本性质。从这些研究中收集的信息将与针对治疗性纳米钻石颗粒和设备的智能设计的实验验证相结合。该计划将结合纳米钻石和工程教育研究，以培养下一代科学/工程领导者。教育/推广计划将整合教育模块设计、教师客座讲座和定制设计的实验套件，以影响不同的学生群体并增加对纳米技术的兴趣。这些单元还将与合作教师共同设计。单元主题将包括纳米碳材料/设备、纳米生物学等的介绍。从建模/模拟项目目标中获得的图像将用于完成直观地说明纳米技术概念的挑战。模块/实验工具包的实施将由博士后研究人员和研究生协调，并将与西北工程教育研究中心合作进行推广计划效果的反馈/分析。