Collaborative Research: Tribologically Durable UHMWPE Nanocomposites for Total Joint Replacements: Nano-mechanics and Bio-tribological Modeling

合作研究：用于全关节置换的耐摩擦 UHMWPE 纳米复合材料：纳米力学和生物摩擦学建模

• 批准号: 0856510
• 负责人: Weihong (Katie) Zhong
• 金额: --
• 依托单位: Washington State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0856510&HistoricalAwards=false
• 关键词: Collaborative; Research; Tribologically; Durable; UHMWPE

Collaborative Research: Tribologically Durable UHMWPE Nanocomposites for Total Joint Replacements: Nano-mechanics and Bio-tribological Modeling This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The research objective of this project is to study the nano-mechanics and bio-tribology aspects of graphitic UHMWPE nanocomposites for total joint replacements, and to establish models for the design of tribologically durable materials that can provide longer life expectancy for prosthetic implants. The conventional method for increasing wear resistance of UHMWPE components of total joint replacements is crosslinking UHMWPE material by irradiation followed by re-melting. These methods have resulted in severe problems such as reduced fatigue strength and toughness, as well as the generation of wear debris in the most biologically active size range, raising concerns of osteolysis, bone resorption, and implant loosening. This project aims at solving those problems through studies of nano-mechanics and bio-tribological modeling for durable UHMWPE nanocomposites reinforced by newly developed graphitic nanomaterials. This research will result in a new design methodology for polymer materials used in artificial joints, and thus lead to optimal UHWMPE nanocomposites and dramatically extended life expectancy for total joint replacements. If successful, the results of this project will provide a base for design and development of tribologically durable UHMWPE materials that can lead to longer life spans for a variety of artificial joints to meet a wide range of patient needs. This research will benefit and contribute to bio-engineering, nanotechnology, materials science, heath care system capability, and our society at large. It will also contribute to multi-level education in both ND and WA states. This project will directly involve both undergraduate and graduate students, and will also lead to new lectures for course development in both universities. Native American tribal college students, woman and minority students will benefit from this research through summer workshops

合作研究：用于全关节置换的耐磨UHMWPE纳米复合材料：纳米力学和生物摩擦学建模该奖项由2009年美国复苏和再投资法案（公法111-5）资助。本项目的研究目标是研究用于全关节置换的石墨超高分子量聚乙烯纳米复合材料的纳米力学和生物摩擦学方面，并建立模型，用于设计摩擦学耐用的材料，从而为假体植入物提供更长的预期寿命。提高全关节置换中UHMWPE部件耐磨性的常规方法是通过辐照交联UHMWPE材料，然后再熔融。这些方法导致了严重的问题，例如疲劳强度和韧性降低，以及在最具生物活性的尺寸范围内产生磨损碎屑，引起了对骨质溶解、骨吸收和植入物松动的担忧。本项目旨在通过对新开发的石墨纳米材料增强的耐用UHMWPE纳米复合材料的纳米力学和生物摩擦学建模的研究来解决这些问题。这项研究将为人工关节中使用的聚合物材料提供一种新的设计方法，从而产生最佳的UHWMPE纳米复合材料，并大大延长全关节置换的预期寿命。如果成功，该项目的结果将为设计和开发摩擦学耐用的UHMWPE材料提供基础，这些材料可以延长各种人工关节的使用寿命，以满足广泛的患者需求。这项研究将有利于和有助于生物工程，纳米技术，材料科学，医疗保健系统的能力，以及我们的社会。它还将有助于ND和WA州的多层次教育。该项目将直接涉及本科生和研究生，并将导致在两所大学的课程开发新的讲座。美洲土著部落的大学生、妇女和少数民族学生将通过夏季讲习班从这项研究中受益