Pulse Laser Driven Ultrafast Micro and Nanofluidic Systems

脉冲激光驱动的超快微纳流体系统

• 批准号: 0901154
• 负责人: Pei-Yu Chiou
• 金额: $ 30万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0901154&HistoricalAwards=false
• 关键词: Pulse; Laser; Driven; Ultrafast; Micro

This objective of this research is to investigate micro- and nano-fluidic devices utilizing ultrafast laser cavitation phenomena and their applications for biomedical research. The approach is utilizing laser cavitation effects originating from breakdown of water molecules in high optical intensity regions through nonlinear optical processes. Intellectual Merit:Micro and nanoscale explosive vapor bubbles can be excited in nanoseconds by highly focused laser beams that are spatially patterned and synchronized in time to achieve functional microfluidic devices with ultrahigh speed that could not be achieved by any other physical mechanisms. The proposed laser cavitation based microfluidic devices provide paradigm-shifting performance for high speed microfluidic actuation by harvesting the mechanical energy during rapid vapor bubble explosions. This enables sorting of 10,000~100,000 cells/sec on a single chip for the first time. Ultrafast laser cavitation actuation can be driven by a compact, portable, and electrically pumped two dimensional laser array for parallel pumping of a large scale microfluidic device, solving one of the major miniaturization issue of microfluidic systems by completely eliminating the bulky pumps and control valves. Broader Impacts:Results and expertise developed during the course of this project will be incorporated into the PI?s teaching activities at both the undergraduate and graduate levels. Minority graduate and undergraduate students will participate in these projects through the outstanding outreach program at UCLA. Students involved in this project will be exposed to an excellent multidisciplinary training environment between the UCLA Medical School and Engineering School.

本研究的目的是探讨利用超快激光空化现象的微纳流体器件及其在生物医学研究中的应用。该方法是利用激光空化效应起源于水分子在高光强区通过非线性光学过程的击穿。智力优势：微米和纳米级爆炸性蒸汽气泡可以在纳秒内被高度聚焦的激光束激发，这些激光束在空间上形成图案并在时间上同步，以实现任何其他物理机制都无法实现的超高速功能微流体设备。 所提出的基于激光空化的微流体装置通过在快速蒸汽气泡爆炸期间收集机械能来提供用于高速微流体致动的范式转换性能。这是首次在单个芯片上实现10，000 ~ 100，000个细胞/秒的分选。 超快激光空化驱动可以由紧凑、便携和电泵浦的二维激光阵列驱动，用于大规模微流体装置的并行泵浦，通过完全消除笨重的泵和控制阀来解决微流体系统的主要小型化问题之一。更广泛的影响：在本项目过程中开发的结果和专业知识将被纳入PI？的教学活动在本科生和研究生水平。少数民族研究生和本科生将通过加州大学洛杉矶分校的杰出外展计划参与这些项目。参与该项目的学生将接触到加州大学洛杉矶分校医学院和工程学院之间的优秀多学科培训环境。