Mitochondrial proteases and their contribution to protein homeostasis

线粒体蛋白酶及其对蛋白质稳态的贡献

• 批准号: FT0992033
• 负责人: Dr Kaye Truscott
• 金额: $ 48.96万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-07-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0992033
• 关键词: Mitochondrial; proteases; their; contribution; protein

This research will examine how a critically important cellular organelle known as the mitochondrion maintains its functional integrity by sensing and signalling protein perturbations. As mitochondrial dysfunction is central to a number of neurodegenerative diseases understanding the molecular biology of this fundamentally important cellular process could, in the future, provide for better health outcomes for an aging Australian population. The training of post-graduate students is an integral component of this study and thus will contribute to building national research capacity. International collaborations and new discoveries will also contribute to the recognition of Australian research.

这项研究将研究一个至关重要的细胞器，线粒体是如何通过感知和信号传递蛋白质扰动来维持其功能完整性的。由于线粒体功能障碍是许多神经退行性疾病的核心，了解这一基本重要细胞过程的分子生物学可以在未来为澳大利亚老龄化人口提供更好的健康结果。研究生的培训是这项研究的一个组成部分，因此将有助于建立国家研究能力。国际合作和新发现也将有助于承认澳大利亚的研究。