Chikungunya virus disease; the role of proteases and their receptors

基孔肯雅病毒病；

• 批准号: nhmrc : GNT1141421
• 负责人: Dr Natalie Prow
• 金额: $ 68.27万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chikungunya-virus-disease-proteases-receptors/1348376
• 关键词: Chikungunya; virus; disease; role; proteases

Chikungunya virus (CHIKV) is a mosquito borne virus related to the Australian Ross River virus. The arthritic disease caused by these viruses is often poorly managed by current treatments. We have recently identified several proteins call proteases that circulate in the blood of infected people and promote arthritis. If successful the grant will provide new treatment options for these (and perhaps other) diseases using recently developed drugs that inhibit the activity of these proteases.

基孔肯雅病毒（CHIKV）是一种蚊媒病毒，与澳大利亚罗斯河病毒有关。由这些病毒引起的关节炎疾病，目前的治疗方法往往难以控制。我们最近发现了几种被称为蛋白酶的蛋白质，它们在感染者的血液中循环，并促进关节炎。如果成功的话，这笔拨款将为这些（也许还有其他）疾病提供新的治疗选择，使用最近开发的药物来抑制这些蛋白酶的活性。