Complex II proteostasis in mammalian mitochondria.

点击翻译按钮获取中文摘要

Mitochondria are critical for energy transduction and other metabolic processes in eukaryotic cells. The vast majority of proteins that perform these functions are nuclear-encoded and fold and assemble in the mitochondrion after their import. This project aims to determine the interplay between the dynamic and competing processes of protein complex biogenesis and quality control in the assembly of respiratory complex II. The project aims to determine the steps and molecular components of the assembly pathway, uncover the molecular mechanism of the only known flavinylation factor and to establish the impact of proteases on this pathway. The project is significant because an imbalance in mitochondrial protein homeostasis leads to diseases in humans.