Biomaterials Interfaces for Photoactive Proteins

光活性蛋白质的生物材料界面

• 批准号: 0907619
• 负责人: David Cliffel
• 金额: $ 42万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907619&HistoricalAwards=false
• 关键词: Biomaterials; Interfaces; Photoactive; Proteins

This award by the Biomaterials program in the Division of Materials Research to Vanderbilt University is to study PhotoSystem I (PSI) for potential applications in solar energy conversion. PSI is the primary macromolecular system in plants and photosynthetic bacteria for the conversion of sun light to useable energy. The main goal of the project will be to understand the fundamental mechanisms of electron transfer to and from immobilized PSI monolayer and multilayer films during the photosynthesis. With this award, methods will be developed to study higher order oriented multilayer structures of PSI with that mimic larger scale biological structures. The deposited films of PSI will be linked through molecular wires for better connectivity and electron conductivity. The following studies will be carried out with this project: 1) attachment of PSI to gold electrodes that are used as molecular wires; 2) optimization of the photoconversion efficiency for PSI monolayers by electrochemical catalysis; 3) functional imaging of PSI by scanning electrochemical microscopy; and 4) study the mechanism of functional multilayer structures that mimic the larger scale biological structures like the thylakoid membranes. The proposed studies are expected to integrate functional biological systems with molecular and mesoscale materials through ?bottom-up? processing, while maintaining the function of the PSI system. The biomimetic approaches proposed could result in converting sunlight to be a potential useable source of energy.The proposed project is expected to enhance the fundamental understanding of the interface between biological structures and well-controlled, model organic materials. New covalent and biomimetic attachments, along with 2-D crystals and strategies will be investigated and their effects measured through electrochemical procedures. This multidisciplinary research team consists of chemical and biomolecular engineers and chemists from Vanderbilt University and Tennessee State University, the largest HBCU in Tennessee. In addition, a large number of graduate and undergraduate students from these institutions will be trained by the research team. Participation of high school teachers and students in the research activities through different programs such as NSF-funded Research Experiences for Teachers and Vanderbilt Summer Academy is another aspect of the project.

该奖项由范德比尔特大学材料研究部生物材料项目颁发，旨在研究光系统I （PSI）在太阳能转换中的潜在应用。PSI是植物和光合细菌中将太阳光转化为可用能量的主要大分子系统。该项目的主要目标是了解光合作用过程中固定化PSI单层和多层膜之间电子转移的基本机制。有了这个奖项，将开发方法来研究高阶取向的PSI多层结构，模拟更大规模的生物结构。沉积的PSI薄膜将通过分子线连接，以获得更好的连通性和电子导电性。本项目将进行以下研究：1)将PSI附着在作为分子线的金电极上；2)电化学催化优化PSI单层膜的光转化效率；3)扫描电化学显微镜下PSI的功能成像；4)研究模拟类囊体膜等大型生物结构的功能多层结构的机理。拟议的研究有望通过自下而上的方式将功能生物系统与分子和中尺度材料结合起来。处理，同时保持PSI系统的功能。提出的仿生方法可以将阳光转化为潜在的可用能源。拟议的项目有望加强对生物结构和良好控制的模型有机材料之间界面的基本理解。新的共价和仿生附着物，以及二维晶体和策略将被研究，并通过电化学程序测量它们的效果。这个多学科研究团队由来自范德比尔特大学和田纳西州最大的HBCU田纳西州立大学的化学和生物分子工程师和化学家组成。此外，研究团队还将培养大量来自这些机构的研究生和本科生。高中教师和学生通过不同的项目参与研究活动，如nsf资助的教师研究经历和范德比尔特暑期学院是该项目的另一个方面。