RUI: Enhancing Enantioselectivity in Lewis Acid Catalysis Through Multiple Asymmetric Induction

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。在这个由化学系无机、生物无机和金属有机化学项目资助的RUI项目中，瓦萨学院的Joseph Tanski将开发改进的方法，在催化系统中使用匹配的手性配体集进行立体选择性甲基化(双重非对映选择性)。合成了三类手性配体，并制备了它们与均相的钛、钪、钴手性醇盐的配合物，并对其进行了表征。然后将在醛的甲基化中筛选这些络合物，并建立结构-活性关系。这项研究将对不对称催化领域产生影响，该领域在化学合成和医药工业中具有重要意义。该项目还将影响本科生的教育，让他们接触不对称催化领域，并为他们提供使用X射线衍射方法确定结构的培训。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). In this RUI project funded by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division, Joseph Tanski of Vassar College will develop improved methods for stereoselective methylation using matched sets of chiral ligands in a catalytic system (double diastereoselectivity). Three classes of chiral chelating ligands will be synthesized, and their complexes with homoleptic titanium, scandium or ytterbium chiral alkoxides will be prepared and characterized. These complexes will then be screened in methylations of aldehydes, and structure-activity relationships will be developed. This research will impact the field of asymmetric catalysis, which is important in the chemical synthesis and pharmaceutical industries. This project also will impact the education of undergraduate students by exposing them to the field of asymmetric catalysis and by providing them with training in structure determination using X-ray diffraction methods.