Chemical Mechanisms of Reactive Sulfur Species

活性硫的化学机理

• 批准号: 0911328
• 负责人: Michael Ashby
• 金额: $ 45.8万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911328&HistoricalAwards=false
• 关键词: Chemical; Mechanisms; Reactive; Sulfur; Species

In this project funded by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division, Michael T. Ashby of the University of Oklahoma will study the reaction mechanisms of sulfur species of fundamental chemical interest that are implicated in biological antimicrobial processes. The understanding of sulfur species reactivity under physiological conditions is very limited, even though they are implicated in cellular damage processes. The information gained from these studies will find application in biological/medical fields, and such studies will also enhance fundamental knowledge of sulfur chemistry. The PI will be involved in graduate student and postdoctoral training and has a track record of broadening the participation of underrepresented groups in chemistry.

在这项由化学部无机、生物无机和金属有机化学项目资助的项目中，俄克拉荷马大学的迈克尔·T·阿什比将研究与生物抗菌过程有关的具有基本化学意义的硫物种的反应机理。对生理条件下硫物种的反应能力的了解非常有限，即使它们与细胞损伤过程有关。从这些研究中获得的信息将在生物/医学领域得到应用，这些研究还将加强硫化学的基础知识。PI将参与研究生和博士后培训，并有扩大未被充分代表的群体参与化学的记录。